Androgens have been implicated in increasing ovarian cancer risk; however, results from prospective studies have been inconclusive. The authors examined whether plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, and dehydroepiandrosterone sulfate were associated with risk of epithelial ovarian cancer in a nested-case control study, using data from three prospective ...

INTRODUCTION The hypothalamic-pituitary-adrenal axis is known to be related to abdominal symptoms, and the relationship between abdominal pain and cortisol secretory patterns has been previously investigated using a cross-sectional approach. Here, we investigated the effect of day-to-day variations in salivary cortisol and dehydroepiandrosterone-sulfate levels on abdominal symptoms in healthy i...

3 H-Androst-5-ene-17-one-3B-pl sulfate is converted to 3B-androst-5-ene-lW-ol-3f3-yl sulfate by soluble extracts of rat testis in the presence of added NAM%2 or NADPH2. The conversion was approximately 4 times greater than the conversion of 3H-androst-5-ene-17-one-3B_ol to 3%androst-5-ene+3@,17&diol under similar incubation conditions. The same extracts converted 3H-androst5-ene-17-one-3@-ol to...

UNLABELLED To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition. METHODS The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A ...

It has been suggested that dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS), have a protec tive effect against breast cancer. In our investigation, DHEAS levels were measured in plasma obtained and frozen in 1972-1974 from 534 women aged 50-79 yr. This group, which has been followed for 15 yr, included 21 incident cases of breast cancer, 20 cases with ...

BACKGROUND We have demonstrated that moderate alcohol consumption (15 g/d, 30 g/d) for 8 weeks resulted in significantly increased levels of serum estrone sulfate and DHEAS in 51 postmenopausal women in a randomized, placebo-controlled trial. We now report on the relationships between serum estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) levels after 4 weeks of moderate alcohol suppl...

OBJECTIVE To determine the role of adrenal androgenic hormone precursors in female sexual function. DESIGN A review of current literature on sexual function and the androgen precursor hormone dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS). RESULT(S) The C(19) steroid DHEA is both an ovarian and adrenal androgen precursor hormone, whereas DHEAS is only synthesized i...