نتایج جستجو برای: dedifferentiation
تعداد نتایج: 2267 فیلتر نتایج به سال:
Objective: To verify whether Chinese rice wine polyphenol compounds (RWPC) could inhibit rat aortic vascular smooth muscle cells (VSMCs) dedifferentiation through mammalian target of rapamycin (mTOR)/P70S6K pathway. Methods: The primary culture and identification of rat VSMCs was conducted and VSMCs in passages 3-5 were used for the following experiments. Platelet derived growth factor-BB (PDGF...
PURPOSE Reprogramming of pigmented epithelial cells (PECs) is a decisive process in newt lens regeneration. After lens removal PECs in dorsal iris dedifferentiate and revert to stem cell-like cells, and transdifferentiate into lens cells. Our purpose is to know how global histone modifications are regulated in the reprogramming of PECs. METHODS Iris sections were stained using various histone...
Abstract Background NKX6.1 is a transcription factor for insulin, as well marker ? cell maturity. Abnormal expression in cells, such translocation from the nucleus to cytoplasm or lost expression, has been shown dedifferentiation. Methods We obtained pancreatic sections organ donors and immunofluorescence staining with insulin was performed characterize subjects without type 2 diabetes mellitus...
PURPOSE To examine the ability of retinal pigment epithelial (RPE) cells to modulate Müller cell extracellular matrix contraction through secreted promoters. METHODS Freshly isolated RPE cells were maintained in continuous culture until the morphologic and immunocytochemical changes associated with myofibroblastic dedifferentiation were complete. Secretory products collected from these cells ...
Transcription factors (TFs) are able to regulate differentiation-related processes, including dedifferentiation and direct conversion, through the regulation of cell type-specific transcriptional profiles. However, the functional interactions between the TFs regulating different transcriptional profiles are not well understood. Here, we show that the TFs capable of inducing cell type-specific t...
Although still debated, limb regeneration in salamanders is thought to depend on the dedifferentiation of remnant tissue occurring early after amputation and generating the progenitor cells that initiate regeneration. This dedifferentiation has been demonstrated previously by showing the fragmentation of muscle fibers into mononucleated cells and by revealing the contribution of mature muscle f...
Differentiated epidermal cells can dedifferentiate into stem cells or stem cell-like cells in vivo. In this study, we report the isolation and characterization of dedifferentiation-derived cells. Epidermal sheets eliminated of basal stem cells were transplanted onto the skin wounds in 47 nude athymic (BALB/c-nu/nu) mice. After 5 days, cells negative for CK10 but positive for CK19 and beta1-inte...
According to the latest concepts, for micrometastasis develop into macrometastasis, differentiated cancer cells must revert a dedifferentiated state. Activation of stemness genes plays key role in this transition. Suppression gene expression using microRNAs can become basis development effective anti-metastatic drugs. This article provides an overview existing methods assessing effect on and ce...
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