BACKGROUND AND OBJECTIVES Various phenotypic methods are recommended in the routine practice to detect the ESBL production in gram negative bacilli. Among them, the Double Disc Synergy Test (DDST) which uses the third generation cephalosporins (3GC), is a simple and a reliable method. But the coexistence of AmpC may give false negative results. In such cases, the ESBL detection can be improved ...

References 1 Cuzon G, Naas T, Truong H et al. Worldwide diversity of Klebsiella pneumoniae that produces b-lactamase bla KPC-2 gene. related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden. et al. Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance i...

BACKGROUND Acinetobacter baumannii is an opportunistic microorganism with an increasing role in nosocomial outbreaks. For the last 2 decades, a growing number of carbapenem-resistant A. baumannii strains have been identified, including the metallo-beta-lactamases (MBLs) producers. The study aimed to investigate the genetic relatedness of, and MBLs production among, a collection of A. baumannii ...

conclusions our findings showed a high occurrence of metallo-β-lactamase production among p. aeruginosa isolates in burn patient infections in our region. also, there are p. aeruginosa isolates carrying the bla-vim-1 and bla-vim-2 genes in isfahan province. background metallo-β-lactamase-production among gram-negative bacteria, including pseudomonas aeruginosa, has become a challenge for treatm...

extended-spectrum β-lactamase (esbl)-producing enterobacteria has become a considerable global concern because of their potential dissemination in humans, in domestic animals, wildlife and the environment. the present study aimed to explore the esbl producing  enterobacteria in aquatic sources of bangladesh as the water may be the potential source of dissemination of this alarming antimicrobial...

Background: Extended-spectrum β-lactamase (ESβL) or metallo-β-lactamase (MβL) production by gram-negative bacteria in immunocompromised patients poses a serious therapeutic challenge for infection control and is associated with infections higher morbidity/mortality, especially developing countries. This study aimed to phenotypically evaluate the of ESβL as well MβL 75 bacterial isolates from cl...

INTRODUCTION The aim of this study was to investigate the prevalence of developmental problems and relationship with sociodemographic variables in a community sample of young children. METHODS Participants included 1000 children (558 males, 442 females, age range 1-48 months, mean 18.4 months, SD 7.8 months). Children were referred generally by their parents for developmental evaluation and c...

We describe our five year experience of conducting developmental evaluation clinic at CDC. We have also assessed the prevalence of developmental delay (defined as delay in any two areas in Denver Development Screening Test II [DDST II]), documented the possible prenatal, natal, postnatal risk factors for developmental delay and, also identified the pattern of developmental disorders. A total of...

Metallo beta lactamases (MBL) are enzymes that have wide spread of activity and they confer a high level of resistance to all b-lactams including carbapenem, except aztreonam [1]. MBLs require divalent zinc ion for their enzymatic activity which is not diminished by serine b lactamase inhibitors like salbactam, tazobactam, clavulinic acid etc but is inhibited by metal chelators like EDTA and th...

This study was conducted to detect the prevalence of Metallo-Beta-Lactamases (MBLs) and Extended Spectrum Beta-Lactamases (ESBLs) in bacterial isolates from clinical community settings two communities Delta State, Nigeria. Eighty four obtained blood, urine, wound stool patients subjects were analyzed identified by standard microbiological methods. Carbapenemase detection carried out using modif...