OBJECTIVE To discuss advantages and disadvantages of various routes of administration and delivery systems for acute migraine medications, and to assist family physicians in optimizing treatment for individual patients. QUALITY OF EVIDENCE A MEDLINE search from January 1966 to October 2000 and a Current

OBJECTIVE To outline current approaches to diagnosing and managing delirium in the elderly. QUALITY OF EVIDENCE A literature review was based on a MEDLINE search (1966 to 1998). Selected articles were reviewed and used as the basis for discussion of diagnosis and etiology. We planned to include all published randomized controlled trials regarding management but found only two. Consequently, we ...

OBJECTIVES The purpose of this study was to evaluate the incidence and prognostic implication of diastolic dysfunction (DD) occurring in the first year after transplant. BACKGROUND Diastolic dysfunction is a recognized complication in heart transplant recipients, but its true incidence and natural history has been poorly characterized. We studied the prognostic implication of DD, as defined b...

STUDY OBJECTIVES To determine the relationship between D dimer (DD) status and markers of disease activity in patients with sarcoidosis. DESIGN Prospective, observational analysis. SETTING Pulmonary clinic of a tertiary care, university-affiliated hospital. PATIENTS Consecutive individuals with newly diagnosed sarcoidosis. INTERVENTION Determination of serum DD. MEASUREMENTS AND RESUL...

Bovine digital dermatitis (DD) is a severe infectious disease causing lameness in dairy cattle worldwide and is an important ruminant welfare problem that has considerable economic issues. Bovine DD is endemic in many regions worldwide and it is important to understand this major disease so that effective control strategies can be identified. There is substantial evidence that specific treponem...

The purpose of this paper is to prove the L p (R n ; dd) boundedness, for p > 1, of the non-centered Hardy-Littlewood maximal operator associated with the Gaussian measure dd = e ?jxj 2 dx. Let dd = e ?jxj 2 dx be a Gaussian measure in Euclidean space R n. We consider the non-centered maximal function deened by Mf(x) = sup x2B 1 (B) Z B jfj dd; where the supremum is taken over all balls B in R ...

BACKGROUND AND PURPOSE Accurate assessment of the number and lesion characteristics of brain metastasis is very important in GKS. The purpose of this study was to compare the diagnostic efficacy of DD gadobutrol in the detection of brain metastases compared with a DD 0.5-mol/L gadolinium contrast, gadopentetate dimeglumine. MATERIALS AND METHODS Records of 27 patients (male to female ratio, 1...

BACKGROUND Iron accumulation as seen in genetic haemochromatosis is a major cause of hepatic fibrogenesis. A link between chronic liver disease and Dupuytren's disease (DD) is well established, especially in alcoholics. AIM The aim of the present study was to test the hypothesis that iron accumulation might cause fibrosis of the palmar aponeurosis leading to DD. PATIENTS AND METHODS We exam...

BACKGROUND The incidence of diastolic dysfunction (DD) approaches 40% in patients with cirrhosis. However, the clinical impact of DD remains a subject of considerable debate. Surgery in patients with cirrhosis is innately hazardous. Diastolic heart failure has been linked to increased mortality after transjugular intrahepatic porto-systemic shunt surgery (TIPSS). To date, none of the commonly a...

BACKGROUND Platelet-derived growth factor (PDGF) is a central mediator of mesangioproliferative glomerulonephritis (GN). In experimental mesangioproliferative GN, PDGF-DD serum levels, unlike PDGF-BB, increased up to 1000-fold. METHODS We assessed disease activity in 72 patients with GN, established a novel PDGF-D ELISA and then determined their PDGF-DD levels. In parallel, we studied renal P...