The spindle assembly checkpoint (SAC) delays mitotic progression until all sister chromatid pairs achieve bi-orientation, and while the SAC can maintain mitotic arrest for extended periods, moderate delays in mitotic progression have significant effects on the resulting daughter cells. Here we show that when retinal-pigmented epithelial (RPE1) cells experience mitotic delay, there is a time-dep...

Family businesses are critical to the United States economy, employing 63% of the workforce and generating 57% of GDP (University of Vermont, 2014). Family business continuity, however, remains elusive as approximately 70% of family businesses do not survive the second generation (Poza, 2013). In order to augment our understanding of how next generation leaders are chosen in family businesses, ...

We studied the pathophysiology of aplastic anaemia (AA) in six different pairs relatives without a family history hematologic disorders or congenital AA. Five and four shared HLA-DRB1*15:01 B*40:02 alleles, respectively. Glycosylphosphatidylinositol-anchored protein-deficient blood cells were detected eight 10 patients evaluated. In mother-daughter pair from one family, flow cytometry leukocyte...

The challenge of cell division is to distribute partner chromosomes (pairs of homologues, pairs of sex chromosomes or pairs of sister chromatids) correctly, one into each daughter cell. In the 'standard' meiosis, this problem is solved by linking partners together via a chiasma and/or sister chromatid cohesion, and then separating the linked partners from one another in anaphase; thus, the part...

Significant intrafamilial correlations of left ventricular mass exist in first-degree relatives. However, the specific maternal and paternal influences on left ventricular mass of offspring remain unknown. We therefore evaluated familial aggregation of left ventricular mass by type of familial relation in two European populations. A random sample of 159 nuclear families (250 parents and 321 off...

fairy tales are stories in which metaphysical, paranormal and mysterious events take place and there is no exact time and place; everything is spiritual. the lorestanian story of “daughter of daal” is a tale of the “mythical birth” of a girl from an egg and her being raised by daal (phoenix) in the cave of a caucasus-like mountain. daughter of daal is snared by a hireling hellcat’s deceit, but ...

Line spectrum pairs (LSPs) are the roots (located in the complex-frequency or -plane) of symmetric and antisymmetric polynomials synthesized using a linear prediction (LPC) polynomial. The angles of these roots, known as line-spectral frequencies (LSFs), implicitly represent the LPC polynomial and hence the spectral envelope of the underlying signal. By exploiting the duality between the time a...

The protozoan parasite Giardia intestinalis (also known as Giardia lamblia) is a major waterborne pathogen. During its life cycle, Giardia alternates between the actively growing trophozoite, which has two diploid nuclei with low levels of allelic heterozygosity, and the infectious cyst, which has four nuclei and a tough outer wall. Although the formation of the cyst wall has been studied exten...

We investigate the effect of welfare reform on intergenerational participation, using mother-daughter pairs in Panel Study Income Dynamics. find that a mother’s Aid to Families with Dependent Children/Temporary Assistance for Needy (AFDC/TANF) participation increased her daughter’s odds adult program by roughly 25 percentage points or more, but attenuated this transmission at least 50%. However...