نتایج جستجو برای: das 28
تعداد نتایج: 303679 فیلتر نتایج به سال:
Seit 20 Jahren wird das Phänomen der Softwarealterung in der Forschung überwiegend aus der Perspektive der Softwareentwicklung untersucht. Aus Sicht des IT-Managements ist dies unzureichend, da für das Management komplexer Anwendungslandschaften auch organisatorische, finanzielle und strategische Faktoren zu berücksichtigen sind. In Banken und Versicherungen setzen sich die Anwendungslandschaft...
Zusammenfassung. In diesem Beitrag wird ein Verfahren zur nutzergeführten 3D-Visualisierung von Strukturen innerhalb medizinischer Volumendatensätze vorgestellt. Das Verfahren nutzt das a-priori-Wissen des Anwenders über die Lage der interessierenden Struktur und berechnet davon ausgehend automatisch eine initiale Transferfunktion für die direkte Volumenvisualisierung mittels Volume Rendering. ...
OBJECTIVES To evaluate the effectiveness and safety of tocilizumab in RA patients in clinical practice. METHODS We observed 232 consecutive RA patients who began tocilizumab in three rheumatology centres in Japan for 52 weeks. Clinical, radiographic and functional status and safety were evaluated. RESULTS Mean age of the 232 patients was 59.1 years, mean duration of disease was 12.4 years a...
Objective. To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). This prospective, observational cohort included 96 Mexican-Mestizo patients with moderate or severe rheumatoid arthritis (RA), initiating MTX or LEF, genotyped for IL-6 -174G/C polymorphism by PCR-RFLP. Therapeutic response was strictly defined: on...
Background. TNF-α inhibitors have shown to be effective in reducing disease activity and improving the quality of life. Due to the high costs associated with acquisition of this treatment, this study was undertaken to evaluate the ICER of TNF-α antagonists (etanercept, adalimumab, and infliximab) in improving the quality of life. Methods. The HAQ and SF-36 were administered at phases 1, 2, and ...
OBJECTIVE To compare the SDAI values to DAS28 scores in RA patients undergoing different DMARD regimens. METHODS The SDAI is an unweighted numerical sum of five outcome parameters: tender and swollen joint count (based on 28-joint assessment), patient and physician global assessment of disease activity (visual analogue scale: 0-10 cm) and level of C-reactive protein (mg/dl). 80 patients (F/M ...
The objective of this review is to report on the progress of the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS) Registry data collection and summarize previous research in understanding therapeutic response to DMARDs using clinical and genetic data. The BRASS Registry, established in 2003, is a large, single-centre, prospective and observational cohort of 1100 RA pat...
Background: Patients with rheumatoid arthritis (RA) suffer from wide ranges of autoimmune reactions in joints. The mechanism of which is generally unknown and maybe associated with Treg deregulation. Objective: To compare the frequency of nTregs in peripheral blood of patients with active rheumatoid disease with healthy individuals. Methods: Twenty five newly diagnosed patients with active RA d...
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