OBJECTIVE In skeletal muscles, dantrolene inhibits the exercise-induced membrane translocation of GLUT4. It has been postulated that the inhibitory action of dantrolene on Ca(2+) release from the sarcoplasmic reticulum (SR) causes inhibition of exercise-induced glucose uptake; however, the precise mechanism has not been adequately studied. RESEARCH DESIGN AND METHODS We discovered that dantro...

Geometrical isomers of dantrolene are considered within the constraints density functional theory at level B3LYP/6-31++G(d,p). Dantrolene is a skeletal muscle relaxant which interferes with release calcium ion from sarcoplasmic reticulum. On other hand, some evidence exists that Mg2+-dependent least in certain species. Therefore, present study not only considers geometrical but also focused on ...

Spasticity is a common disabling feature of multiple sderosis. A variety of drugs are in regular use as oral treatment induding badofen, dantrolene, tizanidine, and diazepam. Published evidence of effectiveness is limited. Most trials are of small size, of short duration, and have not reported on functional outcomes. Studies have been published which suggest that badofen, tizanidine, and diazep...

The objectives of the study were to characterize the selectivity of dantrolene to breast cancer resistance protein (Bcrp) and to evaluate whether cerebrospinal fluid (CSF) can be used as a surrogate to assess brain exposures of BCRP and P-glycoprotein (Pgp) substrates. The impact of Bcrp and Pgp on dantrolene exposures in brain and CSF was examined in Bcrp and Mdr1a/1b knockout mice and was fur...

A 55-year-old, malignant hyperthermia-susceptible patient underwent myocardial revascularization without incident. Six hours postoperatively, he developed what was initially diagnosed as an MH crisis, for which he received intravenous dantrolene. The resultant muscle weakness prolonged the duration of postoperative mechanical ventilation and likely contributed to the development of a postoperat...

Germinario, E., A. Esposito, A. Megighian, M. Midrio, R. Betto, and D. Danieli-Betto. Effects of modulators of sarcoplasmic Ca release on the development of skeletal muscle fatigue. J Appl Physiol 96: 645–649, 2004; 10.1152/japplphysiol.00481.2003.—The reduced release of Ca from sarcoplasmic reticulum (SR) is considered a major determinant of muscle fatigue. In the present study, we investigate...