نتایج جستجو برای: danshensu

تعداد نتایج: 110  

Journal: :International journal of clinical and experimental medicine 2015
Jiahui Yu Lingyan Wang Mary Akinyi Yuhong Li Zhenzhen Duan Yan Zhu Guanwei Fan

Danshen has been widely used in the treatment of cardiovascular diseases while Danshensu [3(3,4dihydroxyphenyl) 2 hydroxy propanoic acid, DSS], a major water-soluble component of Danshen has also been explored as an important compound in Danshen. In the present study, DSS was tested in isolated rat hearts of ischemia reperfusion (I/R) model to investigate its cardioprotective activity and explo...

2014
Li-Long Pan Jie Wang Yao-Ling Jia Hong-Ming Zheng Yang Wang Yi-Zhun Zhu

We have previously reported that the danshensu-cysteine conjugate N-((R)-3-benzylthio-1-methoxy-1-oxo-2-propanyl)-2-acetoxy-3-(3,4-diacetoxyphenyl) propanamide (DSC) is a potent anti-oxidative and anti-apoptotic agent. Herein, we further design and asymmetrically synthesize two diastereoisomers of DSC and explore their potential bioactivities. Our results show that DSC and its two diastereoisom...

2017
Jing Wang Pengfei Xu Xinni Xie Jiao Li Jun Zhang Jialin Wang Fan Hong Jian Li Youyi Zhang Yao Song Xiaohui Zheng Yonggong Zhai

BACKGROUND DBZ (Danshensu Bingpian Zhi), a synthetic derivative of a natural compound found in traditional Chinese medicine, has been reported to suppress lipopolysaccharide-induced macrophage activation and lipid accumulation in vitro. The aim of this study was to assess whether DBZ could attenuate atherosclerosis at early and advanced stages. METHODS AND RESULTS The effects of DBZ on the de...

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