نتایج جستجو برای: danmarane sapogenins

تعداد نتایج: 169  

Journal: :Acta biochimica Polonica 2014
Kamil Jatczak Grzegorz Grynkiewicz

Critical survey of a selected class of pentacyclic triterpenes--the oleanane family, is presented based on current literature in order to underline their value for medicinal chemistry and drug development potential. Oleanenes may be considered as a renewable resource of valuable research materials which are structurally diverse, inherently biocompatible and have built-in affinity for many categ...

Journal: :The Journal of organic chemistry 2002
Romana Anulewicz-Ostrowska Izabella Jastrzebska Jacek W Morzycki Jacek Wójcik

Steroidal sapogenins bearing a good leaving group at C23 undergo a completely stereospecific rearrangement under a variety of conditions via a mechanism involving neighboring-group participation by the acetal oxygen atom in the departure of the nucleofuge from C23. The reactions of equatorial (23S)-23-bromo- or (23S)-23-tosyloxyspirostanes with either the alpha (25R) or beta (25S) oriented 25-m...

Journal: :The Onderstepoort journal of veterinary research 1994
C O Miles A L Wilkins G L Erasmus T S Kellerman

Geeldikkop was induced in a sheep by dosing it orally with a crude extract of the steroidal saponins from Tribulus terrestris. GC-MS analysis of the sheep's ruminal contents, bile, faeces and urine for free and conjugated sapogenins, revealed the general features of the metabolic pathway by which diosgenin and yamogenin glycosides were converted into the glucuronides of epismilagenin and episar...

2012
RAM S. JADHAV MD. LIYAKAT AHMED PARAMJYOTHI SWAMY SYED SANAULLAH

The Wattakaka volubilis ethanolic extract (WVEE), Wattakaka volubilis sapogenin mixture (WVSM) and drevogenins (DVG) isolated from Wattakaka volubilis (Linn.f) Stapf. were evaluated for neuropharmacological activities using spontaneous motor activity, rotarod performance, motor performance evolution and muscle relaxant test models in mice. Sapogenins seemed to be responsible for neuropharmacolo...

2012
Anil K. Singh Durga N. Dhar

The modification and enhancement of biological activity [1,2] of steroidal drugs containing nitrogen atom represent one of the most fruitful developments in medicinal chemistry. Voluminous literature [3] is available on azasteroids. However, a limited work is reported [4-8] about the preparation of aza derivatives corresponding to steroidal sapogenins. This prompted us to make an attempt in thi...

Journal: :Molecules 2016
Luis Sánchez-Sánchez María Guadalupe Hernández-Linares María L Escobar Hugo López-Muñoz Edgar Zenteno María A Fernández-Herrera Gabriel Guerrero-Luna Alan Carrasco-Carballo Jesús Sandoval-Ramírez

Steroidal sapogenins have shown antiproliferative effects against several tumor cell lines; and their effects on human cancer cells are currently under study. Changes in the functionality on the steroidal structure make it possible to modify the biological activity of compounds. Herein, we report the synthesis and in vitro antitumor activity of two steroidal oxime compounds on cervical cancer c...

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