The state of autoreactivity innate immunity dominates in the pathogenesis immunoinflammatory rheumatic diseases, inducing non-infectious “sterile” inflammation. distinctive properties this inflammation include multiorgan affection and recurrent clinical course. extracellular intracellular “danger signals” called DAMPs, seem to be a key factor progression inflammatory events. These factors are r...

BACKGROUND Damp building-related respiratory illnesses are an important public health issue. OBJECTIVE We compared three respiratory case groups defined by questionnaire responses [200 respiratory cases, 123 of the respiratory cases who met the epidemiologic asthma definition, and 49 of the epidemiologic asthma cases who had current physician-diagnosed asthma with post-occupancy onset] to a c...

Many studies have shown a relation between damp housing and health, however, there has been relatively little research concerned with the eVect of cold homes on health. Recent evidence has suggested that inability to keep a house warm is more strongly associated with health outcomes than is damp housing. This paper aims to assess the relation between housing characteristics and ill health focus...

1. The dephosphorylation of 3'-AMP, 3'-dAMP, 3'-CMP and 3'-dCMP was studied in the postmicrosomal supernatant of rat spleen and liver. In both organs 3'-AMP and 3'-dAMP were dephosphorylated at an appreciable rate, in both the presence and the absence of Mg(2+). The pH optimum for this dephosphorylation was in the range 4.5-5.0. 3'-CMP and 3'-dCMP were very slowly degraded, though the activity ...

As sessile organisms, plants have evolved effective mechanisms to protect themselves from environmental stresses. Damaged (i.e., wounded) plants recognize a variety of endogenous molecules as danger signals, referred to as damage-associated molecular patterns (DAMPs). ATP is among the molecules that are released by cell damage, and recent evidence suggests that ATP can serve as a DAMP. Although...

Persistent oscillation in constant conditions is a defining characteristic of circadian rhythms. However, in plants transferred into extended dark conditions, circadian rhythms in mRNA abundance commonly damp in amplitude over two or three cycles to a steady state level of relatively constant, low mRNA abundance. In Arabidopsis, catalase CAT3 mRNA oscillations damp rapidly in extended dark cond...

Damage-associated molecular pattern molecules (DAMPs) signal the presence of tissue damage to induce immune responses in plants and animals. Here, we report that High Mobility Group Box 3 (HMGB3) is a novel plant DAMP. Extracellular HMGB3, through receptor-like kinases BAK1 and BKK1, induced hallmark innate immune responses, including i) MAPK activation, ii) defense-related gene expression, iii...

world apricot (prunus armeniaca l.)  production is increasing steadily due to breeding of new high yielding cultivars in different countries. more recently, breeding programs have been modified according to consumers’ demands and also improvement in resistance to diseases (sharka, monilinia etc.), frost damages, and determination of self-(in) compatibility. in this study, fourteen apricot breed...