DNA adenine methyltransferase (Dam) plays an important role in physiological processes of Gram-negative bacteria such as mismatch repair and replication. In addition, Dam regulates the expression of virulence genes in various species. The authors cloned the dam gene of Yersinia enterocolitica and showed that Dam is essential for viability. Dam overproduction in Y. enterocolitica resulted in an ...

a painful 'sore' on the medial aspect of his left little toe over the preceding month but had pain in the toe intermittently for some years. At the time of presentation the toe was attached only by a piece of thick skin on the lateral side of the toe, good volume peripheral pulses were present in the foot and sensation was normal (Fig. 1). He had no significant past medical history. Radiologica...

[Purpose] This study examined the relationship between toe grip strength and its associated factors by focusing on factors that were suggested to have a relationship with toe grip strength in previous studies, aiming to clarify the factors influencing the toe grip strength of healthy women. [Subjects and Methods] Twelve healthy young women were selected for this study. Their toe grip strength, ...

[Purpose] The aim of this study was to compare toe grip strength and muscle activity during toe grip strength exertion according to the presence/absence of an ankle immobilization belt and to examine the relationship between the differences in muscle activity and toe grip strength. [Subjects] The Subjects were 13 healthy young women. [Methods] We measured toe grip strength and muscle activity d...

This paper firstly described the dam break in the aspects of theories and models. Break parameters prediction, the understanding of dam break mechanics, peak outflow prediction were shown as the essential for the dam break analysis, and eventually determined the loss of the damages. Secondly, as an application example, Foster Joseph Sayers Dam break was further modeled and analyzed using USACE ...

BACKGROUND Decision-analytic modelling (DAM) has become a widespread method in health technology assessments (HTA), but the extent to which modelling is used differs among international HTA institutions. In Germany, the use of DAM is optional within HTAs of the German Institute of Medical Documentation and Information (DIMDI). Our study examines the use of DAM in DIMDI HTA reports and its effec...

DNA adenine methylase (Dam(-)) mutants of Salmonella enterica are attenuated in the mouse model and present multiple virulence-related defects. Impaired interaction of Salmonella Dam(-) mutants with the intestinal epithelium has been tentatively correlated with reduced secretion of pathogenicity island 1 (SPI-1) effectors. In this study, we show that S. enterica Dam(-) mutants contain lowered l...