BACKGROUND The appropriate tropism of adeno-associated virus (AAV) vectors that are systemically injected is crucial for successful gene therapy when local injection is not practical. Acidic oligopeptides have been shown to enhance drug delivery to bones. METHODS In this study six-L aspartic acids (D6) were inserted into the AAV2 capsid protein sequence between amino acid residues 587 and 588...

Background: The appropriate tropism of adeno-associated virus (AAV) vectors that are systemically injected is crucial for successful gene therapy when local injection is not practical. Acidic oligopeptides have been shown to enhance drug delivery to bones. Methods: In this study six-L aspartic acids (D6) were inserted into the AAV2 capsid protein sequence between amino acid residues 587 and 588...

The D6-brane spectrum of type IIA vacua based on twisted tori T̃ 6 and RR background fluxes is analyzed. In particular, we compute the torsion factors of Hn(T̃ 6,Z) and describe the effect that they have on D6-brane physics. For instance, the fact that H3(T̃ 6,Z) contains ZN subgroups explains why RR tadpole conditions are affected by geometric fluxes. In addition, the presence of torsional (co)ho...

Fetal loss in animals and humans is frequently associated with inflammatory conditions. D6 is a promiscuous chemokine receptor with decoy function, expressed in lymphatic endothelium, that recognizes and targets to degradation most inflammatory CC chemokines. Here, we report that D6 is expressed in placenta on invading extravillous trophoblasts and on the apical side of syncytiotrophoblast cell...

We study N=1 supersymmetric four-dimensional solutions of massive Type IIA supergravity with intersecting D6-branes in the presence NS-NS three-form fluxes. We derive N=1 supersymmetry conditions for the D6-brane and flux configurations in an internal manifold X6 and derive the intrinsic torsion (or SU(3)-structure) related to the fluxes. In the absence of fluxes, N=1 supersymmetry implies that...

OBJECTIVE The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and target them for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies. METHODS The current study was carried out in 35 pregnant women (23 patients with preeclampsia and 12 healthy, normotensive pregnant women) during t...

The objective was to investigate effects of progesterone (P4) dose on abundance luteinizing hormone receptor (LHCGR), aromatase (CYP19A1), 3β-hydroxysteroid dehydrogenase (HSD3B1), and other steroidogenic mRNA transcripts in granulosa cells from dominant follicles. Nellore heifers were assigned one six groups: new, first-use controlled internal drug release device (CIDR1) inserted for 5 days (L...

The release of siloxane from landfill leachate has attracted wide attention. In this study, dodecamethylcyclohexasiloxane (D6) and dodecamethylpentasiloxane (L5) were chosen as the target pollutants to investigate adsorption characteristics cyclosiloxane linear on municipal solid waste (MSW) under circumstance. behavior could be well described by Langmuir–Freundlich model, with a maximum capaci...

We construct 1/8, 1/4, and 1/2 BPS solutions spanned by diagonal elements of U(N) constant fluxes in the 6+1 dimensional U(N) super Yang-Mills theory on T 6 with topological stability. These solutions represent BPS bound states of D0, D2, D4, and D6 branes. The consistency with the D-brane charge conservation implies that unstable D0-D2-D6-brane systems in a B field decay to the BPS solutions, ...