نتایج جستجو برای: d2
تعداد نتایج: 17821 فیلتر نتایج به سال:
Dysregulation of dopamine transmission is thought to contribute to schizophrenic psychosis and drug dependence. Dopamine release is regulated by D2 dopamine autoreceptors, and D2 receptor ligands are used to treat psychosis and addiction. To elucidate the long-term effects of D2 autoreceptor activity on dopamine signaling, dopamine overflow evoked by single or paired-pulse stimulation was compa...
The precise localization of D1 and D2 dopamine receptors within striatal neurons and circuits is crucial information for further understanding dopamine pharmacology. We have used subtype specific polyclonal and monoclonal antibodies against D1 and D2 dopamine receptors to determine their cellular and subcellular distributions, their colocalization, and their differential connectivity with motor...
مقدمه: دوپامین درسیستم اعصاب مرکزی نقش مهمی درتعدیل دریافت غذا داشته وگیرنده های دوپامینی در سراسر هیپوتالاموس توزیع شده اند.در این میان رسپتورهای d2 دوپامینی در هسته ی پاراونتریکولار هیپوتالاموس (pvn) بطور چشمگیری بیان شده اند. با توجه به نقش احتمالی این گیرنده ها در تعدیل دریافت غذا از سویی و امکان بالقوه استفاده از این گیرنده ها به عنوان اهداف فارماکولوژیک در معضل چاقی، هدف ازمطالعه حاضر بر...
the objectives of the present study were to evaluate spring wheat recombinant inbred lines (rils) of diverse origin by estimating genetic parameters viz., variability, character association, cluster analysis, and principal component analysis (pca) for spot blotch resistance and yield components at bhu agricultural research farm during 2010-2011. grain yield per plot was significantly and positi...
پارک ملی دریاچه ارومیه با توجه به شرایط زیست محیطی خاص حاکم بر منطقه یک اکوسیستم منحصر به فرد محسوب می شود. پارک ملی دریاچه ارومیه دارای طیف وسیعی از شرایط محیطی طبیعی تا فرانرمال را با محدوده غلظت نمک بین 120 تا 300 گرم در لیتر را شامل می شود. این مطالعه به منظور شناسایی مخمرهای آسکومیستی ساکن خاک های فوق شور در این منطقه انجام پذیرفته است. نمونه های خاک از بخش های مختلف حاشیه دریاچه و همچنین ...
Dopamine receptor subtypes have been classified generally as D1-like (e.g., D1, D5) or D2-like (D2, D3, D4), and converging evidence suggests that D2-like receptors may be especially important in mediating the abuse-related effects of cocaine. However, it has been difficult to differentiate the roles of the D2-like receptor subtypes in the behavioral effects of cocaine because of the relatively...
The D2 dopamine receptor (D2 DAR) is one of the most validated drug targets for neuropsychiatric and endocrine disorders. However, clinically approved drugs targeting D2 DAR display poor selectivity between the D2 and other receptors, especially the D3 DAR. This lack of selectivity may lead to undesirable side effects. Here we describe the chemical and pharmacological characterization of a nove...
introduction: the hippocampus (hip), the primary brain structure related to learning and memory, receives sparse but comprehensive dopamine innervations and contains dopamine d1/d2-like receptors. it is demonstrated that dopamine receptors in dentate gyrus (dg) region of hip have a remarkable function in spatial reward processing. much less is known about the involvement of hip and its d1/d2 do...
Type II deiodinase (D2) activates thyroid hormone by converting thyroxine (T4) to 3,5,3'-triiodothyronine (T3). This allows plasma T4 to signal a negative feedback loop that inhibits production of thyrotropin-releasing hormone (TRH) in the mediobasal hypothalamus (MBH) and thyroid-stimulating hormone (TSH) in the pituitary. To determine the relative contributions of these D2 pathways in the fee...
Let In be the (big) diagonal ideal of (C). Haiman proved that the q, t-Catalan number is the Hilbert series of the graded vector space Mn = ⊕ d1,d2 (Mn)d1,d2 spanned by a minimal set of generators for In. We give simple upper bounds on dim (Mn)d1,d2 in terms of partition numbers, and find all bi-degrees (d1, d2) such that dim (Mn)d1,d2 achieve the upper bounds. For such bi-degrees, we also find...
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