PURPOSE This randomized phase II study evaluated ASA404 (vadimezan; 5,6-dimethylxanthenone-4-acetic acid) in combination with docetaxel in castration-refractory metastatic prostate cancer (CRMPC). EXPERIMENTAL DESIGN Seventy-four patients with histopathologically confirmed CRMPC previously untreated with chemotherapy were randomized to receive either<or=10 cycles of docetaxel 75 mg/m2 alone (...

Background: SEN virus (SENV) is the latest virus proposed as a cause of unknown hepatitis cases. Among nine detected genotypes of the virus, genotypes D and H are more frequent in hepatitis cases of unknown origin. The aim of this study was to determine the frequency of SENV-D and SENV-H genotypes in the sera of healthy individuals and hepatitis B and C patients. Methods: Totally, 200 serum sam...

The O antigen unit of Pseudomonas aeruginosa serotype O5 is a complex trisaccharide containing 2-acetamido-3-acetiminido-2, 3-dideoxy-beta-D-mannuronic acid, 2-acetimido-3-acetimido-2, 3-dideoxy-beta-D-mannuronic acid, and 2-acetimido-2, 6-deoxy-beta-D-galactosamine. Specific knockout mutations in the putative UDP-D-N-acetylglucosamine (UDP-D-GlcNAc) epimerase gene, wbpI, or the putative UDP-D-...

Vitamin D plays an important role in supporting the immune system. Its expression on vital cells like B, T, and antigen-presenting has become topic of research response to current COVID-19 pandemic. The purpose vitamin is not only bones muscle development, but also its involvement regulation mood

Abbreviations: BC: Bladder Cancer; MIBC: Muscle-Invasive BC; NMIBC: Nonmuscle-Invasive BC; BPH: Benign Prostatic Hyperplasia; CT: Computed Tomography; CEA: Carcinoembryonic Antigen; CA19-9: Carbohydrate-Antigen 19-9; HCC: Hepatocellular Carcinoma; TCC: Transitional Cell Carcinoma; UC: Urotherial Carcinoma; Hex: Hexose; Man: D-mannose; Gal: D-galactose; HexNAc: N-acetylhexsosamine; GlcNAc: N-ace...

The priming of an immune response against a major histocompatibility complex class I-restricted antigen expressed by nonhematopoietic cells involves the transfer o f that antigen to a host bone marrow-derived antigen presenting cell (APC) for presentation to CD8 + T lymphocytes. Dendritic cells (DC), as bone marrow-derived APC, are first candidates for presentation o f tumorassociated antigens ...

After immunization, normal H-2 heterozygous mice (for example H-2(b) x H-2(d)) generate two populations of cytotoxic effector T cells, one specific for target cells expressing H-2(b)-plus-antigen and the other specific for H- 2(d)-plus-antigen. With a multideterminant antigen, these two populations have about the same activity. We show here that the H-2 type of resident cells in the thymus dete...