benzodiazepines are useful drugs for treatment of sleep disorders, anxiety, seizure cases and skeletal muscle cramps. some derivatives of 2-(2-phenoxy) phenyl-1, 3, 4-oxadiazole were synthesized as benzodiazepine receptor agonists. conformational analysis and superimposition of energy minima conformers of the compounds on estazolam, a known benzodiazepine agonist, reveal that the main proposed ...

background: vibrio paraheamoloyticus is one the causative agents of vibriosis with high mortality in farmed fish and shrimp and under predisposing conditions.                                  objectives: this study was aimed to assess the effect of gamma irradiation on the inactivation of v.  paraheamoloyticus under fresh and freeze-dried conditions. methods: vials of 0.5 ml fresh culture of th...

introduction: astrocytes are the most abundant glial cell type. in addition to their neurological roles, astrocytes also have immune functions. they have been involved in antigen presentation in the central nervous system (cns). activated astrocytes express adhesion molecules, chemokines and release several inflammatory mediators, pro-inflammatory cytokines, neurotrophic and neuroprotective fac...

results at high concentrations (40 and 100 μm), apoptosis was demonstrated and it was clearly more prominent in hepatocytes exposed to celecoxib loaded liposomes. conclusions our results showed that celecoxib loaded liposomes robustly induced apoptosis, an action that can potentially make it more relevant than the usual form for chemopreventive strategies and also may raise concerns about its t...

objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...

this research in order to identify and introduction of  cotton  suitable cultivar  or cultivars for the double cropping of after wheat and canola harvesting  was carried out in the northern region of ardebil province. in this study, eight  varieties  of    imported cotton germplasm resources in recent years were chosen   and   with the iran's cultivars included  mehr  and varamin  were eva...

the most conveni ent me thod f or d e t ermining bone dose duri ng ext ra-oral . radi ogr aphy is ph o togr aph~c r adiation desimetry.this met hod was used bec ause, it is cheap,srnall l i ghtweight a nd adequately sens itive a nd i t a l s o prov i des a p e rmanent r ecor ds ( l o}. i t i s evident f r om thi s r eport tha t a r e l a tionsh i p e xist s between the bone and s k i n dose , a...

conclusions according to the results, the polymorphisms within the +49 position of ctla-4 can be associated with vl and may be considered as risk factors for the disease. results our results indicated that both ctla-4 +49a/g polymorphisms were significantly associated with vl. materials and methods in this cross-sectional study, 88 patients with clinical presentations of vl, who were seropositi...

chromium (cr) is one of the elements presents in crust of the earth. due to its toxicity, chromium is considered as water contaminant that may disturb metabolic activity. in the present study, adsorption of dissolved chromium (vi) onto elaeagnus angustifolia fruit charcoal, jujube fruit charcoal and the standard granular activated carbon (gac) has been investigated and compared. the effect of c...