The biomedical application of high-voltage nanosecond pulsed electric fields (nsPEFs) has become an emerging interdisciplinary research field in recent years. Compared with microsecond and millisecond fields, nsPEFs can not only lead the cell membrane structure to polarize dielectric break down structure, i.e. electroporation, but also penetrate into cell, triggering off organelle bioelectrical...

ABSTRACT Cell and tissue functions rely on the genetic programmes cascades of biochemical signals. It has become evident during past decade that physical properties soft material govern mechanics cells tissues play an important role in cellular function morphology. The biophysical are determined by cytoskeleton, consisting dynamic networks F-actin microtubules, molecular motors, crosslinkers ot...

Neurons are the “delicate and elegant…butterflies of soul,” as Santiago Ramón y Cajal famously put it in his memoir ([Zwirn, 2015][1]). interconnect throughout brain body via elaborate arborization their dendrites axon. Their cytoskeleton, intricate array

T he protein WHAMM serves as an intermediary between the microtubule and actin cytoskeletons. Shen et al. discover that binding to microtubules changes WHAMM’s interactions with actin, offering insight into how cells keep the two cytoskeletons in sync (1). Researchers have mainly studied the microtubule and actin cytoskeletons separately. For example, they’ve uncovered how actin dynamics shape ...

This review highlights genes, proteins and subcellular mechanisms, recently shown to influence cortical neuronal migration. A current view on mechanisms which become disrupted in a diverse array of migration disorders is presented. The microtubule (MT) cytoskeleton major player migrating neurons. Recently, variable impacts MTs have been revealed different cell compartments. Thus there are multi...

Mechanical homeostasis-a fundamental process by which cells maintain stable states under environmental perturbations-is regulated by two subcellular mechanotransducers: cytoskeleton tension and integrin-mediated focal adhesions (FAs). Here, we show that single-cell mechanical homeostasis is collectively driven by the distinct, graduated dynamics (rheostasis) of subcellular cytoskeleton tension ...