background: rheumatoid arthritis (ra) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. there are controversial data about the profile of interleukin-17 (il-17a), interleukin-4 (il-4), and interferon-gamma (infî³), indicating in some studies the key role of il-17, while in others the th1 cyt...

objective(s):sublingual allergen-specific immunotherapy is a safe and effective method for treatment of ige-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. this study was planned to test whether sublingual immunotherapy (slit) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. materials and methods:balb/c...

Murine CD4+ T cells have two distinct cytokine secretion patterns to play different functions. We demonstrated that cold-induced stress (CIS) suppresses the immune system leading increased intensity of Chlamydia muridaum in mice. reported beta2-adrenergic receptor (b2-AR) knockout (KO) mice resist chlamydia genital infection. However, profile is not well explored. This study aimed determine pro...

background:it has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing chronic myelogenous leukemia (cml). in this regard, th1 and th2 cytokines and their gene polymorphism seems to be important. overall expression and secretion of cytokines is dependent, at least in part, on genetic polymorphism (nucleotide variations) w...

Cytokines are key factors in the cross talk between the immune system and other systems including hepatic, nervous, cardiac and cutaneous systems, leading to an adaptive and integrated response of the organism to stress. They are also involved in the regulation of many processes, including hematopoiesis, the immune response and inflammation. IL-10 is one of the most important anti-inflammatory ...