the aquatic environment 2 3 4 5 Reviewed version of manuscript ENVPOL-D-09-00080R1. 6 The abstract of this paper was evaluated and approved by Dr Wiegand. 7 8 9 Authors 10 11 Jean-Philippe BESSE a* 12 Jeanne GARRIC a** 13 14 a Unité Biologie des écosystèmes aquatiques. Laboratoire d’écotoxicologie, 15 Cemagref, 3bis quai Chauveau CP 220 69336 Lyon cedex 09, France 16 Tel.: +33 472208902 17 18 *...

Little information is available on the environmental occurrence and ecotoxicological effects of pharmaceutical gestagens released in the aquatic environment. Since eighteen different gestagens were found to be used in France, preliminary exposure and hazard assessment were done. Predicted environmental concentrations (PECs) suggest that if parent gestagens are expected to be found in the ng l(-...

BACKGROUND During pregnancy there is a high demand for docosahexaenoic acid (DHA), which is needed for formation of the fetal brain. Women who do not consume marine foods must synthesize DHA from fatty acid precursors in vegetable foods. OBJECTIVE We studied sex differences in DHA status and the role of sex hormones. DESIGN First, DHA status was compared between 72 male and 103 female healt...

A new class of antiandrogen medications, gonadotropin-releasing hormone agonists, offers promise in the treatment of the paraphilias, with substantially less side effects than medroxyprogesterone acetate or cyproterone acetate. This paper reports the results of treatment using a depot suspension of leuprolide acetate on 12 patients with paraphilic disorders or with sexual disorders not otherwis...

Draft of March 11, 2001. We still plan to make considerable changes to this manuscript. Comments and list of typos are welcome!