Here we report on the genomic structure of the bovine aromatase cytochrome P450-encoding gene (Cyp19) and its tissue-specific transcript variants. The gene comprises at least 14 exons (1.1, 1.2a, 1.2b, 1.3,1.4, and 2-10) spanning more than 56 kilobases of genomic DNA. The coding area is confined to exons 2-10. Transcriptional start sites of Cyp19 were examined in granulosa cells, placenta, test...

The CYP19 gene encodes for aromatase (P450arom), a key steroidogenic enzyme that catalyzes the final step of estrogen biosynthesis. Apart from rare mutations in CYP19 which result in severe phenotypes associated with estrogen insufficiency, little is known about whether common variation in CYP19 is associated with risk of hormone-related diseases. In this study, we employed a haplotype-based ap...

PURPOSE To evaluate the efficacy of treatment with the aromatase inhibitor letrozole in breast cancer patients segregated with respect to DNA polymorphisms of the aromatase gene CYP19. PATIENTS AND METHODS Postmenopausal patients (n = 67) with hormone receptor-positive metastatic breast cancer were treated with the aromatase inhibitor letrozole. PCR allelic discrimination was used to examine ...

this study was performed to investigate two polymorphic sites from cyp19 gene (pvuii and mspi) and one polymorphic site from erα gene (snabi) in four cattle breeds including mazandarani, taleshi, sistani and simmental. in overall 278 samples for cyp19 and 206 samples for erα marker sites were genotyped using polymerase chain reactionsingle-strand conformation polymorphism (pcr-rflp) procedure. ...

Female cancers such as breast (BC), endometrial (EC) and ovarian (OC) cancers show a growing incidence rate all over the world including Russia. In Novosibirsk city the incidence of BC, EC and OC is approximately 80, 25 и 12 per 100 000 in female population, respectively. In Novosibirsk population EC is most commonly found between the ages of 55 and 60 years, OC – between 45-60 and 55-60 years,...

Background: Nano-particle Titanium Dioxide (TiO2) is a noncombustible, odorless powder that is widely used in different fields of industries. Previous reports showed that chronic exposure to TiO2 adversely impacts the testicular tissue and down-regulates the antioxidant capacity and down-regulates the endocrine status of the testicles. Present study was designed in order to identify the role of...

DAX-1 [dosage-sensitive sex reversal, adrenal hypoplasia congenita (AHC) critical region on the X chromosome, gene 1] is an orphan nuclear receptor that represses transcription by steroidogenic factor-1 (SF-1), a factor that regulates expression of multiple steroidogenic enzymes and other genes involved in reproduction. Mutations in the human DAX1 gene (also known as AHC) cause the X-linked syn...

BACKGROUND In view of the important function of nuclear receptor liver receptor homolog 1 (LRH 1) in various biological processes and the physiological changes accompanying unexplained recurrent spontaneous abortion (USRA), our study was carried out to investigate the potential roles of LRH-1 in USRA. MATERIAL AND METHODS Thirty patients with URSA at early the early state of pregnancy were sele...

INTRODUCTION Several studies have reported an increase in breast cancer (BC) risk when patients are carriers of the CYP19 TTA polymorphism with ≥10 repeats; moreover, it has been reported that telomere length is associated with a higher susceptibility of developing cancer. OBJECTIVE The objective of this study was to understand the relationship between CYP19 TTTA repetition polymorphism and t...