نتایج جستجو برای: cyclooxygenase 2 inhibition
تعداد نتایج: 2760582 فیلتر نتایج به سال:
Objective: Inflammation plays a crucial role in the progression of many diseases, excessive inflammation increases immune cell activation, which can destroy tissues and body health. When occurs, multiple pro-inflammatory mediators are overproduced, leading to variety diseases such as rheumatism, diabetes, cardiovascular problems. Brucea javanica has been used traditional medicine therapy for an...
The increase in cerebral blood flow (CBF) during neuronal activation can be only partially attenuated by individual inhibitors of epoxyeicosatrienoic acids (EETs), cyclooxgenase-2, group I metabotropic glutamate receptors (mGluR), neuronal nitric oxide synthase (nNOS), N-methyl-D-aspartate receptors, or adenosine receptors. Some studies that used a high concentration (500 μM) of the cyclooxygen...
C yclooxygenase (COX) catalyzes the conversion of ara-chidonic acid to prostaglandin H 2 , which is then further metabolized by downstream synthase enzymes to a range of eicosanoids. COX is expressed in 2 isoforms, constitutive COX-1 and inducible COX-2. Nonsteroidal anti-inflamma-tory drugs (NSAIDs) are widely used to treat inflammation and pain and show potential to prevent cancer. COX-2 is t...
Aspirin inhibits platelet function by permanently acetylating the cyclooxygenase that forms prostaglandins. We determined the sensitivity of platelets to aspirin in normal subjects by measuring [3H-acetyl]aspirin-susceptible cyclooxygenase in washed platelets obtained at various times after aspirin ingestion. A single 325-mg aspirin dose inactivated 89% of platelet cyclooxygenase. The inhibitio...
background there are hoarding documents for the biological importance of cyclooxygenase-2 (cox-2) in pancreatic carcinogenesis. we aimed to thoroughly investigate the dna sequence variations of whole cox-2 exons in a large case-control study of pancreatic cancer by direct sequencing. methods the entire exonic regions of cox-2 including 10 exons were sequenced in the germline dna of 96 patient...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید