To solve the problem of delivering pharmacologically promising 3ʹ,5ʹ-cyclic diadenosine monophosphate (cyclo-diAMP) to target cells in humans and animals, complexes above-mentioned dinucleotide with natural polymer – chitosan were originally synthesized by ionotropic gelation technique. It was found that binding degree cyclo-diAMP this biopolymeric carrier reaches 60 %; wherein capacity obtaine...

Purpose: To synthesize chloro-pyrazolines (A–D), determine their antimalarial activity against Plasmodium falciparum strain 3D7 in vitro, and understand the interaction between falcipain-2 active sites synthesized compounds by molecular docking simulation.Methods: Chloro-pyrazolines (A–D) were via cyclo-condensation of 4-chloro chalcone derivatives using several types hydrazines, i.e., formylhy...

The condensation reaction of aceto-phenone (1-phenyl-ethan-1-one) with 2-nitro-benzaldehyde in the molten state yielded the expected chalcone, (E)-3-(2-nitro-phen-yl)-1-phenyl-prop-2-en-1-one, and, unexpectedly, the title compound, C30H22N2O6, which results from the syn head-to-head [2 + 2] cyclo-addition of the chalcone. The mol-ecular structure of the dimer shows that the four benzene rings o...

The title compound, C(19)H(15)Cl(2)N(3)O(2), was obtained by a one-step cyclo-condensation of 2-amino-1-(4-chloro-phen-yl)imidazoline with diethyl (2-chloro-benz-yl)malonate under basic conditions. In the crystalline state, the mol-ecule exists as the 7-hy-droxy-5-oxo tautomer. The dihedral angles between the fused imidazopyrimidine and aromatic chloro-phenyl and chloro-benzyl rings are 14.2 (1...

The Second Law of thermodynamics implies that no thermodynamic system with a single heat source at constant temperature can convert into mechanical work in recurrent manner. First, we note this is equivalent to cyclo-passivity the port system, while thermal kept constant. This leads question, which general systems two power ports have similar behavior: when cyclo-passive one its ports, output v...

A convenient and general method for the synthesis in 26-73% yields of a new series of 7-alkyl(aryl/heteroaryl)-2-amino-5-trifluoromethyl-1,8-naphthyridines from direct cyclocondensation reactions of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones [CF₃C(O)CH=C(R¹)OR, where R¹ = H, Me, Ph, 4-MePh, 4-OMePh, 4-FPh, 4-BrPh, 4-NO₂Ph, 2-furyl, 2-thienyl and R = Me, Et] with 2,6-diaminopyridine (2,6-DAP), unde...

Cyclo(His-Phe) was effectively converted to its dehydro derivatives by the enzyme of Streptomyces albulus KO-23, an albonoursin-producing actinomycete. Two types of dehydro derivatives were isolated from the reaction mixture and identified as cyclo(DeltaHis-DeltaPhe) and cyclo(His-DeltaPhe). This is the first report on cyclo(His-DeltaPhe) and the enzymatic preparation of both compounds. Cyclo(D...

(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester(1) upon reaction with ethyl bromoacetate furnishes (7-ethoxycarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid methylester (2), which on treatment with 100% hydrazine hydrate yields (7-hydrazinocarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (3). The condensation of compound 3 with different aromatic aldehydes afforded a se...