Adrenomedullin is a novel hypotensive peptide originally isolated from human pheochromocytoma. Accumulating evidence suggests the possible involvement of adrenomedullin in the physiology of the pulmonary circulation and the pathophysiology of hypoxaemia. The aim of the present study was to investigate the pathophysiological significance of adrenomedullin in hypoxaemia caused by congenital cyano...

Primary cardiac tumors are rare. Of these the majorities are benign and about 75% are atrial myxomas. One of the rarest tumors affecting the heart is a cardiac paraganglioma. We report an unusual case of a left ventricular paraganglioma discovered during autopsy in a 22-year female patient, a case of sudden death. This patient also had coexistent Pentalogy of Fallots along with transposition of...

OBJECTIVE To study the distribution of age, gender, and the relative frequency of congenital heart defects at the time of the diagnosis in Southern Yemeni children. METHODS This retrospective study focused on echocardiographic findings of 393 symptomatic children affected by congenital heart disease. It was conducted in the Echocardiography Department of a referral hospital for Aden city and ...

BACKGROUND Children with cyanotic congenital heart disease and pulmonary outflow tract obstruction have shortened platelet survival times and are susceptible to thrombosis and organ infarction. Thromboxane A2 and prostacyclin have opposing actions on platelet aggregability and an imbalance in their biosynthesis might contribute to the pathophysiology of these complications. METHODS Biosynthes...

Right atrial myxoma is a rare cause of heart failure in infancy and childhood. 1-4 Since its clinical diagnosis is elusive in this age group,4 it is usually not suspected in the differential diagnosis of cyanotic neonates with congestive cardiac failure. The implications, however, of making the diagnosis of this potentially curable tumour during life are obvious. We report a newborn baby with a...