Background: Second only to malaria, cutaneous leishmaniasis is considered the most serious disease in tropical and subtropical areas around the world. Although leishmaniasis is a self-limited disease, the scar left by it on the affected person’s skin can cause mental and emotional problems. The present study investigated the lifetime prevalence of cutaneous leishmaniasis scar among the affected...

background : cutaneous leishmaniasis is one of the prevalent health problems in tropical and subtropical areas including iran. therefore, it is essential to identify the prevalence and new foci of this disease in different regions of iran. this study aimed to determine the epidemiology of cutaneous leishmaniasis by active surveillance in elementary schools in pakdasht city, southeast of tehran,...

BACKGROUND Leishmania (Viannia) species are the principal cause of mucosal leishmaniasis. The natural history and pathogenesis of mucosal disease are enigmatic. Parasitological evaluation of mucosal tissues has been constrained by the invasiveness of conventional sampling methods. METHODS We evaluated the presence of Leishmania in the mucosa of 26 patients with cutaneous leishmaniasis and 2 p...

Leishmania/HIV coinfection is a new clinical form of leishmaniasis that has been reported in more than 35 countries [1,2]. The World Health Organization (WHO) estimates that 39.5 million people are infected by HIV worldwide and that one-third of them live in Leishmania-endemic regions [1,2]. Most of the reported Leishmania/ HIV coinfections were among patients infected with viscerotropic parasi...

BACKGROUND & OBJECTIVES Rapid and accurate diagnosis and identification of Leishmania sp causing cutaneous leishmaniasis is crucial in control and therapeutic programs. The problem of diagnosis with traditional methods is that they have a low sensitivity or time consuming but molecular techniques would be an alternative method for rapid and accurate diagnosis. In this work, tryparedoxine peroxi...

objective(s):to evaluate the effect of trinitroglycerin (tng) as nitric oxide donor agent on serum copper (cu) and zinc (zn) levels and liver enzymes in balb/c mice infected with leishmania major (l. major) mrho/ir/75/er. materials and methods: inbred female mice were divided into three groups: healthy group (uninfected naive mice), control group (infected with l. major), and test group (l. maj...

background: cutaneous leishmaniasis (cl) is one of the most important health problems in different regions of iran that occurs both in zoonotic and anthroponotic forms in different foci of iran. the khuzistan province, located in the south west of iran in vicinity of the persian gulf, is one of the oldest susceptible foci for cl in iran. objectives: due to the lack of information about the cond...

Human leishmaniasis is a spectral disease that includes asymptomatic self-resolving infection, localized skin lesions, and progressive visceral leishmaniasis. With some overlap, visceral and cutaneous leishmaniasis are usually caused by different species of Leishmania. This review focuses on host responses to infection with the species that cause visceral leishmaniasis, as they contrast with sp...

Three species of L. tropica, L. major and L. infantum are known as main causal agents of leishmaniasis have been reported in Iran. Since cutaneous leishmaniasis (CL) is endemic in North East of Iran, in the present work, 50 Leishmania positive isolates from human cases in Mashhad (Center of Razavi province, North East of Iran), were genotyped by means of polymerase chain reaction-restriction f...