A male patient, aged 33, was treated at the Clinic for Oncology, Hematology and Radiotherapy at the University Clinical Center, Tuzla, with the diagnosis of diffuse large B-cell lymphoma. Conformal radiotherapy was conducted on the region of the epipharynx, oropharynx and lymph nodes of the neck on both sides (1). The target volume included the following: the clinical target volume (CTV) of the...

Larynx may alternatively serve as a target or organs at risk (OAR) in head and neck cancer (HNC) image-guided radiotherapy (IGRT). The objective of this study was to estimate IGRT parameters required for larynx positional error independent of isocentric alignment and suggest population-based compensatory margins. Ten HNC patients receiving radiotherapy (RT) with daily CT on-rails imaging were a...

The present study is aimed at determination of accuracy of relocation of Gill-Thomas-Cosman frame during fractionated stereotactic radiotherapy. The study aims to quantitatively determine the magnitudes of error in anteroposterior, mediolateral and craniocaudal directions, and determine the margin between clinical target volume to planning target volume based on systematic and random errors. Da...

BACKGROUND We prospectively reviewed response rates, local control, and side effects after non-fractionated stereotactic high single-dose body radiation therapy for lung tumors. METHODS Fifty-eight patients underwent radiosurgery involving single-dose irradiation. With 25 patients, 31 metastases in the lungs were irradiated; with each of 33 patients, stage I non-small cell lung cancer (NSCLC)...

Establish a comprehensive plan robustness evaluation platform for intensity modulated proton therapy bilateral head and neck cancer based on the daily cone-beam computed tomography: dose accumulation study between PTV IMPT (PTV-IMPT) CTV robust optimized (ro-IMPT) planning strategies

The Gaussian error function model, containing pairs of error and complementary error functions, was used to carry out cumulative dose-volume histogram (cDVH) analysis on prostate intensity modulated radiation therapy (IMRT) plans with interfraction prostate motion. Cumulative DVHs for clinical target volumes (CTVs) shifted in the anterior-posterior directions based on a 7-beam IMRT plan were ca...

BACKGROUND AND PURPOSE To compare partial-breast clinical target volumes generated using a standard 15 mm margin (CTV(standard)) with those generated using three-dimensional surgical excision margins (CTV(tailored 30)) in women who have undergone wide local excision (WLE) for breast cancer. MATERIAL AND METHODS Thirty-five women underwent WLE with placement of clips in the anterior, deep and ...

BACKGROUND To assess the dosimetric effect induced by inter-observer variability in target definition for 3D-conformal RT (3DCRT) and volumetric modulated arc therapy by RapidArc (RA) techniques for rectal cancer treatment. METHODS Ten patients with rectal cancer subjected to neo-adjuvant RT were randomly selected from the internal database. Four radiation oncologists independently contoured ...

BACKGROUND The purpose of this study was to compare outcomes among patients treated by intensity-modulated radiotherapy (IMRT) with daily image-guided radiotherapy (IGRT) for head and neck cancer according to the margins used to expand the clinical target volume (CTV) to create a planning target volume (PTV). METHODS Three hundred sixty-seven consecutive patients were treated with IMRT for sq...

OBJECTIVE We hypothesized that omission of clinical target volumes (CTV) in lung cancer radiotherapy would not compromise control by determining retrospectively if the addition of a CTV would encompass the site of failure. METHODS Stage II-III patients were treated from 2009-2012 with daily cone-beam imaging and a 5 mm planning target volume (PTV) without a CTV. PTVs were expanded 1 cm and te...