________________________________________________________________________________ Abstract Steroidal implants are used extensively in beef cattle management to take advantage of welldocumented improvements in growth performance and efficiency. In addition to muscle growth, steroids bring about changes in bone and cartilage formation, hastening bone ageing. The current study was designed to test ...

background  recent investigations show that both proliferation and secretion of macromolecules by cells can be regulated by low level laser therapy (lllt). the aim of this study was to determine whether lllt could induce a bio-stimulatory effects on human gingival fibroblasts (hgf3-pi 53). therefore, the effect of laser irradiation on human gingival cell proliferation and collagen type i gene e...

BACKGROUND The aims of this study were to establish robust reference intervals and to investigate the factors influencing bone turnover markers (BTMs) in healthy premenopausal Spanish women. METHODS A total of 184 women (35-45 years) from 13 centers in Catalonia were analyzed. Blood and second void urine samples were collected between 8 a.m. and 10 a.m. after an overnight fast. Serum procolla...

Although much has been learned recently of the mechanisms that regulate osteoclastic differentiation, much less is known of the means through which their resorptive activity is controlled. This is especially so for human osteoclasts. We have recently developed an assay that allows us to measure resorptive activity while minimizing confounding effects on differentiation by optimizing osteoclasto...

when grown in monolayer culture at low density and with the addition of serum, cartilage cells dedifferentiate or are overgrown by fibroblast-like cells. the aim of this study was to optimize the cultivation of chondrocytes in monolayer culture and to slow down their transformation or their overgrowth by fibroblast-like cells. the interaction between chondrocytes and cartilage-specifc matrix is...

Background: Lead is one of the sustainable metals with devastating effects on many tissues. This study, examined the adverse effect of lead poisoning on the gene expression of collagen type II and osteocalcin by mesenchymal stem cells (MSCs) cultured in chondrogenic and osteogenic media, respectively. Methods: We used 18 male Wistar rats, divided in 3 groups. In addition to libitum feed as the...

Objective- To determine the effect of collagen type I on hydroxyproline content in Achilles tendon in dogs. Design- Experimental in vivo study. Animals- A total of 12 adult dogs. Procedure- Under general anesthesia and aseptic condition the dorsal surface of right Achilles tendon was exposed and after complete separation of  connective tissue, it was splitted (striking 10 times) in full thic...

serum assay seems to be more restrictive than the urinary assay for detecting products derived from the telopeptide region of collagen type I. The decrease in bone remodeling that occurs in older girls with respect to younger girls is a generally accepted fact. In accordance with the results found in this work in b-CTX and bAP concentrations, it would be possible suggest that serum b-CTX assay ...

Renal osteodystrophy is a multifactorial disorder of bone remodelling that develops in patients with chronic renal failure. During the last few years numerous biochemical markers of bone turnover have been proposed for the non-invasive diagnosis of renal osteodystrophy. Several enzymes and matrix proteins produced by osteoblasts and osteoclasts, including collagen type I degradation products, h...

Rheumatoid arthritis (RA) is associated with a high risk of osteoporosis and fracture. Interleukin (IL)-6 inhibitors may suppress osteoclast activation. Anticitrullinated protein antibody (ACPA) titers are inversely associated with bone mineral density (BMD). However, the differential effect of ACPA on bone turnover marker (BTM) and BMD changes after IL-6 inhibition remains unclear. This prospe...