Cryptorchidism and hypospadias have been related to prenatal estrogen exposure in animal models. Some chemicals used in farming and gardening have been shown to possess estrogenic and other hormone-disrupting effects. Earlier studies have indicated increased risks of urogenital malformations in the sons of pesticide appliers. In the present study, parental occupation in the farming and gardenin...

This paper reports simultaneous occurrence of cryptorchidism and testicular tumor in three brothers within a single family. Two of the brothers had seminoma and the third brother had embryonal carcinoma. Tumor markers such as alpha fetoprotein, assay for beta subunit of human chorionic gonadotrophic hormone, and carcinoembryonic antigen were all negative. The simultaneous occurrence of familial...

Cryptorchidism is the most frequent defect of the male urogenital tract at birth. It represents a risk factor for primitive testiculopathy associated with long-term complications (infertility, testicular neoplasia, and hormonal changes). An only consensus exists: "children with bilateral cryptorchidism who are not treated in early age are certainly set to become infertile". The majority of Auth...

Maternal Alcohol Consumption Linked to Cryptorchidism in Sons Cryptorchidism (undescended testes), the most frequently occurring genital malformation in newborn boys, is a risk factor for later testicular cancer and fertility problems. By some reports, incidence has increased in recent decades, with environmental and lifestyle factors as potential contributors. As part of a broader investigatio...

Cryptorchidism, the failure of one or both testes to descend into the scrotum prenatally, occurs in 2.4%-5% of newborns. Many of these testes will descend spontaneously shortly after birth, but ~23% will remain undescended unless surgery is performed. Bilaterally cryptorchid men have a six times greater risk of being infertile when compared with unilaterally cryptorchid men and the general male...

Cryptorchidism is the most common cause of non-obstructive azoospermia in man. In contrast to the general belief that temperature-dependent effects on the undescended gonad damage cryptorchid testes before sexual maturation is complete, molecular pathology strongly supports the theory that impaired mini-puberty is responsible for azoospermia and infertility in cryptorchidism. Molecular biologic...

The incidence of cryptorchidism in infants is 3.3-5.8%, incidence in adults is not known. Cryptorchidism in adults is not uncommon in India for various reasons. Orchiectomy is the best option as malignant transformation of the undescended testis is a very real risk. Our patient was 52 years old with an empty left hemiscrotum and a large lower abdominal swelling. Laparoscopy-assisted resection w...

Toppari and co-authors recently published a review on ‘‘the environmental connection’’ of cryptorchidism and hypospadias, including the potential adverse effect of alcohol (Toppari et al., 2010). Based on an article by Damgaard et al., 2007, they conclude that: ‘‘mothers’ alcohol consumption caused a dose-dependent increase in the risk of cryptorchidism’’ (Damgaard et al., 2007). We are not con...

PURPOSE Cryptorchidism is one of the most common pediatric disorders of the male endocrine glands and the most common genital disorder identified at birth. This guideline is intended to provide physicians and non-physician providers (primary care and specialists) with a consensus of principles and treatment plans for the management of cryptorchidism (typically isolated non-syndromic). MATERIA...

PURPOSE We evaluated the clinical and therapeutic characteristics of adult cryptorchidism, which have been difficult to establish, given the small number of patients presenting to outpatient clinics. MATERIALS AND METHODS A retrospective study of 20 adult patients with cryptorchid testis was performed. We analyzed their palpation of testis, location, surgical method, marital status, number of...