The present research work aimed to formulate and evaluate a gastro retentive in situ gelling system of Nicardipine Hydrochloride using Sodium Alginate as polymer, HPMC K100M release retard calcium carbonate cross-linking agent, tri-sodium citrate fluidity enhancer agent treat hypertension. mechanism for the floatation was based on ionic cross-linking. Several evaluation tests were carried out p...

The objective of this study is to evaluate the effect of formulation variables on the release characteristics of dexamethasone sodium phosphate (DSP) from chitosan microspheres. Chitosan microspheres containing DSP as the model drug were prepared by using high molecular weight chitosan with Brookfield viscosity 800.000. Microspheres were prepared by w/o emulsion formation followed by cross-link...

In this research, gelatin nanoparticles were synthesized via inverse miniemulsion method by employing a mixture of a water soluble carbodiimide (CDI) and N-hydroxysuccinimide (NHS) as a non-toxic cross-linking system. The gelatin nanoparticles were characterized for their size and size distribution, morphology and stability and were compared with those of nanoparticles cross-linked by glutarald...

The purpose of this study was to improve the entrapment efficiency of the water-soluble drug metronidazole using internal cross-linking agents. Calcium pectinate beads containing metronidazole were prepared by dropping a drug-pectin solution in 1% and 5% (m/V) calcium chloride for surface cross-linked beads. For the core cross-linked beads calcium carbonate was dispersed in the drug-pectin solu...

Poly(vinyl alcohol) hydrogels have a significant range of mechanical properties based on compositional and processing parameters. Biodegradable hydrogels based on Poly(vinyl alcohol) were prepared for controlled drug delivery of bovine serum albumin. These hydrogels were synthesized by a crosslinking technique using glutaraldehyde as a crosslinker. Hydrogels containing drug were prepared by dir...

In this study the viability of using guar gum to form films was investigated along with the effectiveness of the cross-linking process employing 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as the cross-linking agent. In addition, the cross-linked films were evaluated considering the water absorption, thermal stability and mechanical properties. The cross-linking process o...

production and characterization of soft cross-linked gelatin sponge by using glutaraldehyde for blood hemostasis application, is the goal of this study. biodegradable hydrogels were prepared through crosslinking of gelatin with glutaraldehyde followed by freeze drying. the effects of gelatin concentration, amount of crosslink agent and freeze drying temperature on mechanical properties and elas...

SJG-136 (NSC 694501) is a novel DNA cross-linking agent that binds in a sequence-selective manner in the minor groove of the DNA helix. It is structurally novel compared with other clinically used DNA cross-linking agents and has exhibited a unique multilog differential pattern of activity in the NCI 60-cell line screen (i.e., is COMPARE negative to other cross-linking agents). Given this profi...

Purpose: To evaluate g-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs. Experimental Design: g-H2AX foci formationwas validated preclinically in comparisonwith the Comet assay, and evaluated pharmacodynamically in two phase I studies of different dosing schedules of the novel cross-linking agent SJG-136 (SG2000). Results: The measurement of g-...

PURPOSE To evaluate γ-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs. EXPERIMENTAL DESIGN γ-H2AX foci formation was validated preclinically in comparison with the Comet assay, and evaluated pharmacodynamically in two phase I studies of different dosing schedules of the novel cross-linking agent SJG-136 (SG2000). RESULTS The measurement of...