Its empirical formula is C24H28N2O5•HCl, and its molecular weight is 460.96. Benazeprilat, the active metabolite of benazepril, is a non-sulfhydryl angiotensin-converting enzyme inhibitor. Benazepril is converted to benazeprilat by hepatic cleavage of the ester group. Lotensin is supplied as tablets containing 5 mg, 10 mg, 20 mg, and 40 mg of benazepril hydrochloride for oral administration. Th...

Silymarin, an extract of the seeds of Silybum marianum L. (milk thistle), is used for treatment of liver diseases. It contains several active flavonolignans; the major are silybin, which is a mixture of diastereomers A and B, and silychristin. Low bioavailability of silybin and silychristin is related to low water solubility of these compounds. In order to enhance the solubility, S. marianum dr...

Carbamazepine belongs to the class II biopharmaceutical classification system (BCS) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. The bioavailability of such a drug is limited by the dissolution rate. In order to increase the drug dissolution, its solid dispersions were prepared by the cogrinding technique using an insoluble but highl...

Carbamazepine belongs to the class II biopharmaceutical classification system (BCS) which is characterized by a high per-oral dose, a low aqueous solubility and a high membrane permeability. The bioavailability of such a drug is limited by the dissolution rate. In order to increase the drug dissolution, its solid dispersions were prepared by the cogrinding technique using an insoluble but highl...

Naproxen sodium is an analgesic NSAID (non steroidal anti inflammatory drug) used for the treatment of pain, inflammation, fever and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, juvenile arthritis, gout, migraine and dysmenorrhea. However, the gastric discomfort caused by drug results in poor patient compliance associated with its conventional dosage forms. Hence...

Orodispersible tablets (ODT) of levocetirizine was prepared using natural polysaccharides ipomoea batatas starch, amorphophallus campanulatus starch and their modified form by direct compression method and evaluated for their superdisintegrant activity. Levocetirizine dihydrochloride was used as a model drug. The prepared formulations were compared with synthetic superdisintegrants such as cros...

The objective of this study was to evaluate and compare the effect of four superdisintegrants such as croscarmellose sodium (Ac-Di-Sol), crospovidone (Kollidon CL and with smaller particle sizes Kollidon CL-F), sodium starch glycolate (Explotab) in combination with β-lactose and microcrystalline cellulose (Avicel PH-102) as base excipients exhibiting properties of directly compressed tablets an...

In the treatment of type 2 diabetes mellitus a continuous therapy is required which is a more complex one. As in these patients there may be a defect in both insulin secretion and insulin action exists. Hence, the treatment depends on the pathophysiology and the disease state. In the present study, multilayered tablets of pioglitazone hydrochloride 15 mg and metformin hydrochloride 500 mg were ...