This is the second of two articles that together aim to explore current understanding of the clinical value of measuring serum/plasma urea concentration. The main focus of the first article [1] was physiological topics, such as urea production and renal processing of urea. The causes of increased and reduced plasma/serum urea concentration were also discussed. The main focus of this second arti...

In order to enlarge the scope of the calorimetric method for the determination of creatinine and creatine it is, I think, necessary to replace the bichromate standard with standard creatinine solutions, and in the next two papers will be described various adaptations of the method based on this principle. In connection with this work I have again gone over the subject of the preparation of crea...

This study was designed to test the hypothesis that, in a patient with decreased renal function and an increased plasma creatinine concentration, a significant quantity of creatinine is excreted into the gut, as is true of urea and uric acid, and is metabolized by gut flora. [Methyl14C]creatinine was given intravenously to five patients and [methyl-14C] creatinine or Lcarbony!-14C] creatinine w...