Background: Most cancer studies focus on exploring non-invasive biomarkers for cancer detection. In the present study, we sought to investigate the expression level of microRNA-21 (miR-21), as a potential diagnostic marker, in serum and stool samples from 40 patients with colorectal cancer (CRC) and 40 healthy controls. Methods: Quantitative real-time RT-PCR was applied to determine the relativ...

Introduction Colorectal carcinoma (CRC) is one of the most common cancers that involve human body. Young-onset CRC (YO-CRC) or early-onset (EO-CRC) defined as develops before age 50 years, opposed to diagnosed after 50, referred late-onset (LO-CRC). EO-CRC sparsely studied in our population. Therefore, this study, we evaluated clinicopathological parameters and biomarker profile compared them w...

Background and Purpose: The present study aimed to evaluate the consistency with which physiotherapists apply manual hyperinflation to a test lung using the AirViva-2 or Mapleson-B resuscitation circuit, and their ability to modify the technique as pulmonary characteristics change. Method: A quasi-experimental, randomized, repeatedmeasures design was used to study 16 volunteer physiotherapists ...

Background and Purpose. Physiotherapists use a variety of techniques aimed at improving lung volumes and secretion clearance in patients after surgery. Periodic continuous positive airway pressure (PCPAP) is used to treat patients following elective upper abdominal surgery. However, the optimal method of application has not been identified, more specifically, the dosage of application of PCPAP....

Background & Aims: Many studies have demonstrated that Vitamin D has an important role in cell growth and proliferation and vitamin D receptor polymorphism has significant relationship with colorectal cancer (CRC). The aim of this study was to assess the incidence of VDR rs 2238136 polymorphism in Iranian population and to investigate the relationship between this single nucleotide polymorphism...

background: colorectal cancer (crc) is a common and lethal malignancy worldwide. the incident rate of crc is different in various geographica regions. crc is a multifactorial disease; the factors involved included dietary and genetic factors. p53 gene is the most important tumor suppressor gene which involved in many cancers. the mutation rate in exons 7 and 8 of p53 gene in crc was reported to...

colorectal cancer (crc) is a third most common epithelial carcinoma. crc is known to develop from the early precancerous lesion to full blown malignancy via definite phases due to cumulative mutations and aberrant methylation of number of genes. the use of serum biomarkers that is non-invasive to discriminate cancer patients from healthy persons will prove to be an important tool to improve the...