UNLABELLED Atypical teratoid/rhabdoid tumor is predominantly a childhood tumor and has only been rarely reported in adults; therefore, treatment regimens are often extrapolated from the pediatric experience. Typically, children are treated with craniospinal radiation therapy which is often followed by systemic chemotherapy. Employing pediatric regimens to treat this tumor in adult patients pose...

In this study, the efficacy of computed tomography (CT) and magnetic resonance imaging (MRI) in the evaluation of craniospinal involvement with polyostotic fibrous dysplasia (PFD) in McCune-Albright syndrome (MAS) and related complications were reviewed. In CT, ground-glass appearance with well-defined borders was seen, with medullary widening and cortical thinning. More rarely, cystic/necrotic...

BACKGROUND Cranial reirradiation is clinically appropriate in some cases but cumulative radiation dose to critical normal structures remains a practical concern. The authors developed a simple technique in 3D conformal proton craniospinal irradiation (CSI) to block organs at risk (OAR) while minimizing underdosing of adjacent target brain tissue. METHODS Two clinical cases illustrate the use ...

230 2013 Mayo Foundation for Medical Education and Research. Siyong Kim, PhD, owns interests of Medical Tool and Technology, LLC. The other authors have no conflicts of interest to disclose. Submitted November, 27, 2013, Accepted December, 6, 2013 Corresponding Author: Jennifer L. Peterson, Department of Radiation Oncology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA Tel: +1-904...

BACKGROUND The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into the normal tissue complication probability (NTCP), the accuracy and safety of treatment plan evaluations concerning the effect of repair can be improved. This study aims to evalu...

Xanthoma disseminatum is a rare normolipemic histiocytic disorder of non-Langerhans cell origin. It is a chronic systemic disease with a benign course, characterized by disseminated, yellow-orange-colored papules on the face, flexures, and mucosal membranes. We report 3 patients with xanthoma disseminatum, who presented primarily with central nervous system disease and a multitude of imaging fi...

Communicating hydrocephalus and/or papilloedema associated with intraspinal tumours is rare. Four such patients are presented in this article. In addition to previous theories put forward to explain this condition, we would like to propose alteration of craniospinal compliance distribution as a possible underlying mechanism. Consequently, we suggest not performing shunt placement immediately if...