Autophagy is a catabolic process through which damaged organelles and protein aggregates are delivered to lysosomes for degradation. Autophagy genes are reported to promote exposure of "eat me" signals on the surface of apoptotic cells, but whether they function in engulfing cells is not clear. Recently, we found that the autophagy mutants atg-18 and epg-5 are defective in removing apoptotic ce...

To support police in reenacting criminal acts is one of the most important functions of forensic investigation. This case report deals with the discovery of the corpse of a 42-year old man at the bank of the river Inn. First of all the man was supposed to be drowned, but the autopsy showed a gunshot wound of the neck and a shot-through of the brain-stem. Intensive search for the weapon by the p...

Necrophagous species of insects provide useful complementary data to estimate the postmortem interval in forensic cases. Here, for the first time, we report on insect specimens collected from human corpses in Riyadh, Kingdom of Saudi Arabia. During the study, 14 beetle larvae were collected from the outdoor corpse (case report one) and five flies and seven beetles were collected from the indoor...

When a corpse is discovered, investigators have to identify the victim to determine the cause of the death and to estimate the post mortem interval. If the corpse is in an advanced decay, estimating the post mortem interval using common techniques becomes rather difficult. In this regard, insects picked up by the cadaver can be of great help. Forensic entomology studies the successive arrivals ...

To permit quick identification of arthropods, random amplified polymorphic DNA typing (RAPD) was used to support classical morphological and medico-legal analysis of maggots on a human corpse. The method was employed to determine if maggots which were found on the inside of a body bag were identical (a) with maggots found on the outside of the bag, and (b) pupae found on the floor under the cor...

Background: Uncontrolled cell proliferation and resistance to apoptosis are the main characteristics of cancer cells. Therefore, a substance with the capability to induce apoptosis in cancer cells could be known as an anti-cancer material. Probiotics are useful microorganisms that are crucial for the host’s health.Materials and Methods: In the present stu...

Despite its unlikely occurrence, post-mortem animal depredation is not unknown to forensic pathologists. In the case at issue, the corpse of a dead woman presented extensive facial wounds, which were then traced back to the dog she owned. A small specimen of injured tissue was subjected to species diagnosis, and came back positive for human and canine antigens, which confirmed the presence of b...

During apoptosis, dying cells are swiftly removed by phagocytes. It is not fully understood how apoptotic cells are recognized by phagocytes. Here we report the identification and characterization of the Caenorhabditis elegans ttr-52 gene, which encodes a transthyretin-like protein and is required for efficient cell corpse engulfment. The TTR-52 protein is expressed in, and secreted from, C. el...

The area of forensic entomology has developed to become an increasingly important aspect of forensic science. Insect larvae and adult insects found on human corpses can provide crucial information for the post-mortem interval (PMI) estimation. In July 2010, a decomposing female corpse was found in Xiangjiang River of Changsha section. The main larvae found on the corpse were identified to be Bo...

Temperature-based estimation of time of death (ToD) can be performed either with the help of simple phenomenological models of corpse cooling or with detailed mechanistic (thermodynamic) heat transfer models. The latter are much more complex, but allow a higher accuracy of ToD estimation as in principle all relevant cooling mechanisms can be taken into account. The potentially higher accuracy d...