The purpose of this study is to evaluate the feasibility of percutaneous antegrade myocardial gene transfer (PAMGT). A consistent and safe technique for in vivo gene transfer is required for clinical application of myocardial gene therapy. PAMGT with concomitant coronary venous blockade was performed in 12 swine. The myocardium was preconditioned with 1 min of occlusion of the left anterior des...

Of 19,994 percutaneous transluminal coronary angioplasty procedures performed in The Netherlands between April 1980 and January 1989, the long-term follow-up of 454 patients who underwent angioplasty of greater than or equal to 1 saphenous vein bypass graft was reviewed. In 46% of patients single graft angioplasty was attempted, and in 54% of patients sequential graft angioplasty was attempted....

BACKGROUND Although distal embolization and the "no-reflow" phenomenon are well described in saphenous vein graft (SVG) interventions, the frequency, magnitude, and characterization of embolized debris have not been evaluated in routine coronary interventions. A unique embolus protection device described herein provides a means of containing and retrieving plaque material dislodged during percu...

background: c linical trials of revascularization have routinely under-enrolled elderly subjects. thus, symptom relief and improved survival might not apply to elderly patients, in whom the risk of mortality and disability from revascularization procedures seems to be high and co-morbidity is more prevalent. the present case control study was performed to draw a comparison in terms of the proce...

In a model of early and aggressive vein graft stenosis in pigs, an intervention was performed with a single stent (n = 12 grafts), multiple stents (n = 6), or balloon angioplasty (n = 6), while grafts with mild stenoses were left untreated (n = 8). Four weeks after intervention, angiography showed that grafts with single stents, balloon angioplasty, or untreated grafts had patency rates of 92%,...

arterial sclerosis has been extensively described but reports on venous sclerosis are very sparse. phlebosclerosis refers to the thickening and hardening of the venous wall. despite its morphological similarities with arteriosclerosis and potential morbid consequences, phlebosclerosis has gained only little attention. we report a 72 year old male with paralysis and atrophy of the right leg due ...

When performing percutaneous coronary revascularization, physicians nearly always supplement balloon angioplasty with a stent.1 This decision is based on evidence that stent implantation enhances the procedural success and durability of angioplasty. Benefits of stenting, compared with balloon angioplasty, include a reduction in the incidence of lesion recurrence, manifested as reduced need for ...

introduction : significant left main coronary artery stenosis jeopardizes the entire myocardium of the left ventricle and has the worst prognosis of any form of coronary artery disease. coronary-artery bypass grafting (cabg) has been considered as the standard therapeutic approach for such patients. there are limited data on the safety and effectiveness of percutaneous coronary intervention (pc...

background: the drug-eluting stent (des) decreases the rate of coronary restenosis and re-obstruction. the aim of this study was to assess prospectively the effectiveness of the new generation des on the left ventricular (lv) systolic and diastolic functions in patients with isolated severe proximal left anterior descending (lad) coronary artery stenosis. methods: a prospective study was conduc...