Introduction: In the Kindling-induced seizure model, low and repeated electrical or chemical stimulations, can elevate the neural network excitability and induce epileptiform seizures. Opioid receptors are widely distributed in different areas of the brain. On the other hand, morphine has paradoxical effects and induces elevation or alleviation of the pain sensation and excitability, at diff...

Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...

Objective(s):A growing interest has recently been attracted towards the identification of plant-based medications including those with protective effects against cognitive impairment. Sesamol has shown promising antioxidant and neuroprotective effects, therefore, we aimed to evaluate its therapeutic potential in epilepsy which is commonly associated with oxidative stress and cognitive impairmen...

In the present study, Panax ginseng was evaluated for its antiepileptic activity against pentylenetetrazole (PTZ) induced chemical kindling in rats. PTZ was injected at the dose of 30 mg/kg, i.p. on alternate days and the occurrence of generalized tonic clonic convulsions were considered as the end point. One group received Panax ginseng every day, at a dose of 100 mg/kg, 30 min prior to PTZ in...

(1) Objectives: Epilepsy disorder is likely to increase with aging, leading to an increased incidence of comorbidities and mortality. In spite of that, there is a lack of information regarding this issue and little knowledge of cognitive and emotional responses in aging subjects following epileptogenesis. We investigated whether and how aging distress epilepsy-related behavioral and biochemical...

temporal lobe epilepsy (tle) is a disorder of the central nervous system in which hippocampus is mostly involved and causes memory impairment. kindling is a model of inducing epilepsy which is created through pentylenetetrazol (ptz) administration. this study examines the role of the aqueous extract of boswellia on the learning and development of brain (formation of dendritic branches and axons...

Sildenafil is the first marketed phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction and recently, for pulmonary hypertension. While the treatment was found to be highly effective, several adverse effects are associated with this compound. Among numerous central nervous system-related untoward effects, proconvulsant activity was reported. The purpose of this study was to ass...

Background: Norhraman is an alkaloid that can damage the nervous system. Objective: This experimental study aimed to investigate effects of prenatal norharman exposure on seizure severity in adult rats. Methods: A total 36 Wistar rats were randomly divided into 3 groups as follows: Control, sham (solvent), and (1000 ug/kg). The treated once daily for 8-18 fetal period. 2 months after birth, kin...