A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoa...

The first enantioselective synthesis of the anti-Helicobacter pylori agent (+)-spirolaxine methyl ether has been carried out in a convergent fashion by heterocycle-activated Julia olefination of a spiroacetal-containing sulfone fragment with a phthalide-containing aldehyde fragment. The total synthesis of (+)-spirolaxine methyl ether establishes the absolute stereochemistry of the natural produ...

This paper presents some interesting results of numerical analysis of the Extended Blaschke functions, which are constructed by extending Blaschke product. On the complex plane, the convergent domains of the functions form fractal patterns of constrained Herman rings with limited-layered structures, which demonstrate skip-symmetry, symmetry broken, chaos, and degeneracy in conjunction with para...

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time.

A sequence of Sonogashira coupling, Pd(II)-catalyzed carbonylative annulation, and benzofuran reduction (Mg, MeOH, NH(4)Cl) provides a convergent and modular synthetic route to trans-2-aryl-2,3-dihydrobenzo[b]furan-3-carboxylates, which are a structural feature of numerous biologically active natural products. This versatile strategy was applied to the formal total synthesis of the anti-HIV nat...

A convergent and enantioselective synthesis of the natural product amurensinine is described. The synthetic strategy takes advantage of mild and selective C-H and C-C bond insertion reactions, in addition to the palladium-catalyzed aerobic oxidative kinetic resolution recently developed in these laboratories.

The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.

Wnt genes play important roles in regulating patterning and morphogenesis during vertebrate gastrulation. In zebrafish, slb/wnt11 is required for convergence and extension movements, but not cell fate specification during gastrulation. To determine if other Wnt genes functionally interact with slb/wnt11, we analysed the role of ppt/wnt5 during zebrafish gastrulation. ppt/wnt5 is maternally prov...

The notion of a free product of pro-finite groups has some important applications in the theory of algebraic number fields (see [3]). In this connection, it is interesting to get some knowledge about the subgroups of such a free product. The aim of this paper is to show a theorem for the open subgroups of a free pro-finite product, which is an analog of Kurosh’s wellknown subgroup theorem for t...

The standard de nition of convergence of an in nite product of scalars is extended to the in nite product P= n=1Bn of k × k matrices; that is, P is convergent according to the de nition given here if and only if there is an integer N such that Bn is invertible for n¿N and P= limn→∞ m=NBm is invertible. A family of su cient conditions for this kind of convergence is given, along with examples sh...