Estrogen appears to enhance cerebral blood flow (CBF). An association between CBF and physiologically altered hormonal levels due to menstrual cycle, menopause, or exogenous manipulations such as ovariectomy or hormone replacement therapy has been demonstrated. The purpose of this study was to determine the association between ovarian stimulation and CBF in vivo by measuring blood flow in the i...

Background: To study the effectiveness of Clomiphene citrate (CC) in preventing a premature LH surge during controlled ovarian stimulation in women undergoing assisted reproduction. Materials and Methods: Couples were randomized to receive human menopausal gonadotrophins (hMG) followed by CC or hMG alone till the day of hCG. The primary outcomes were the incidence of a clinical pregnancy and pr...

Ovarian hyperstimulation syndrome (OHSS) is still a severe complication due to controlled ovarian stimulation for artificial reproductive technology. Even though multiple techniques to avoid OHSS have been discussed in the last decades, up to now no clear concepts for primary and secondary prevention exist. This review gives an overview over proposed strategies to avoid OHSS. In a retrospective...

BACKGROUND The aim of this study was to evaluate the effect of ovarian stimulation with LH-containing gonadotropins (human menopausal gonadotropin, hMG), on ploidy of human cleavage-stage-embryos. METHODS A total of 104 women, at ages 27-43 years, undergoing one cycle of controlled ovarian hyperstimulation for IVF in combination with preimplantation genetic diagnosis, were eligible for enroll...

BACKGROUND Poor ovarian response to controlled ovarian stimulation is one of the most important interest points in assisted reproduction. Mild ovarian stimulation seems to be preferable to high dose of FSH regimens in women with a history of poor ovarian response in previous protocol. Clomiphene citrate and letrozole alone or in combination with FSH have been used in mild ovarian stimulation pr...

advantages of mild-stimulation have long been appreciated, while there was a called for more patient-friendly approach in ovarian stimulation around 20 years ago (1)...

Cancer is not uncommon and no longer considered to be an incurable disorder. 10% of cancer cases occur under the age of 45. There is a remarkable improvement in treatment and survival rates. Today women have been delaying initiation of childbearing because the incidence of most cancers increases with age. Delayed childbearing results in more female cancer survivors. As a consequence there is an...