نتایج جستجو برای: contractile functions
تعداد نتایج: 511361 فیلتر نتایج به سال:
Definition of the contractile state of the myocardium from force, length, and velocity relationships and measurements of ventricular pressure is a continuum mechanics approach that requires a detailed knowledge of the system under consideration or, in the absence of detailed knowledge, the use of suitable conceptual models. In this paper we proposed a simpler, though still rigorous, approach th...
Chronic volume overload (VO) on the left ventricle (LV) augments redox stress and activates matrix metalloproteinase (MMP) which causes the endocardial endothelial-myocyte (EM) disconnection leading to myocardial contractile dysfunction. VO-induced MMP-9 activation impairs cardiac functions, in part by endothelial endocardial apoptosis, but the role of MMP-9 on EM functions remains obscure. We ...
Leiomodin 2 (Lmod2) is an actin-binding protein that has been implicated in the regulation of striated muscle thin filament assembly; its physiological function has yet to be studied. We found that knockout of Lmod2 in mice results in abnormally short thin filaments in the heart. We also discovered that Lmod2 functions to elongate thin filaments by promoting actin assembly and dynamics at thin ...
Two functions are proposed for the conserved family of UCS proteins: helping to fold myosin motor proteins and stimulating the motor function of folded myosins. We examined both functions in yeast. The fission yeast UCS protein (Rng3p) concentrates in nodes containing myosin-II (Myo2) and other proteins that condense into the cytokinetic contractile ring. Both the N-terminal (central) and C-ter...
Skeletal muscles are diverse in their properties, with specific contractile characteristics being matched to particular functions. In this study, published values of contractile properties for >130 diverse skeletal muscles were analyzed to detect common elements that account for variability in shortening velocity and force production. Body mass was found to be a significant predictor of shorten...
Background & Aims: Considering the higher incidence of cardiovascular disorders in diabetes mellitus and some evidence on antioxidant and antidiabetic potential of Tribulus terrestris (TT), this study was conducted to evaluate the beneficial effect of 6-week oral administration of TT on contractile reactivity of isolated thoracic aorta in diabetic rats. Methods: Female Wistar rats were divided ...
Background: It is generally accepted that the selective adenosine triphosphate-dependent potassium channel openers (KATP openers) have a dramatic role in the treatment of some cardiovascular disorders. The aim of this study was to investigate the effects of diazoxide, a potent ATP-related potassium channel opener, on spontaneously beating isolated rat atria to achieve more accurate approaches t...
in this article, we have focused one some basic and productive information about the properties of spectrum and singular values related to compact operators which are ideals in a c*-algebra of bounded operators. considering a two-sided connection between the family of symmetric gauge functions on sequence of singular values of compact operators and symmetric norms on finite dimensional ope...
angiotensin ii is a major endocrine hormone that affects directly both vascular smooth muscle and endothelial cells. since vascular reactivity to angiotensin ii changes in more physiological and pathophysiological conditions, the present study was performed to investigate the effect of intraperitoneal administration of angiotensin-converting enzyme inhibitor and captopril (30 and 50 mg kg-1, on...
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