AIMS To report the clinical findings and visual outcome of patients with extended wear contact lens (EWCL) related bacterial keratitis. METHODS 11 cases with EWCL related bacterial keratitis were included. Corneal scrapings were obtained for cytology and cultures. RESULTS Nine patients had unilateral bacterial keratitis and two patients showed bilateral involvement. Corneal scrapings reveal...

PURPOSE The purpose of this study is to compare the adhesion capabilities of the most important etiologic agents of microbial ocular infection to the recently available silicone-hydrogel lenses with those to a conventional hydrogel lens. METHODS In vitro static adhesion assays of Pseudomonas aeruginosa 10,145, Staphylococcus epidermidis 9142 (biofilm-positive), and 12,228 (biofilm-negative) t...

PURPOSE Soft contact lenses have been reported to increase the progression of myopia. The purpose of this study was to determine whether soft contact lenses affect the progression of myopia in children. METHODS Children between the ages of 8 and 11 years with -1.00 to -6.00 D myopia and less than 1.00 D astigmatism were randomly assigned to wear soft contact lenses (n = 247) or spectacles (n ...

AIMS A case-control study was performed to evaluate soft contact lens (SCL) wear modality as a risk factor for microbial keratitis. METHODS Contact lens wearers presenting as new patients to Moorfields Eye Hospital accident and emergency department during a 12 month period completed a self administered questionnaire detailing demographic data and contact lens use habits. Cases were patients w...

Uniocular aphakia in the adult when corrected with a contact lens is in most patients no obstacle to binocular function. The long-term result is a balance between binocular function obtained and the comfort of the contact lens, and in this respect the advent of the soft lens, and especially the continuous-wear lens, appears to be most promising.

PURPOSE The authors have previously shown a marked increase in corneal epithelial arachidonic acid metabolism to 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-hydroxyeicosatrienoic acid (12-HETrE) in a model of closed eye-contact lens wear. Their formation was predominantly cytochrome P450-dependent and significantly correlated with inflammatory score and corneal thickness. In the current st...

Inflammatory corneal complications associated with contact lens (CL) wear range from self limiting sterile corneal infiltrative conditions such as infiltrative keratitis (IK), and contact lens-induced acute red eye (CLARE) to severe sight threatening microbial keratitis [1-3]. In practice, managing complications associated with CL wear has been a challenge to practitioners, especially in diagno...

With estimated numbers of contact lens wearers worldwide exceeding 140 million, even complications with a low incidence will affect a significant number of individuals. Although contact lenses clearly have many advantages for wearers, certain risks have been associated with their use. Differences in risk for different types of contact lenses and wearing patterns have been demonstrated for both ...