The definition of the semantics of visual languages, in particular Unified Modeling Language (UML) diagrams, using graph formalism has known a wide success, since graphs fit the multi-dimensional nature of this kind of language. However, constraints written in Object Constraint Language (OCL) and defined on these models are still not well integrated within this graph-based semantics. In this ch...

In multi-station assembly systems, common for mass-customization manufacturing strategies, the product being assembled is held in a fixture attached to a pallet, and the pallet is conveyed between workstations. In high-precision assembly systems, variation in the position of the pallet is one of the largest sources of variation within the error budget, reducing quality and yields. Conventional ...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 the radicular groove is a developmental anomaly that predisposes the tooth to periodontal break-down. sometimes the situation becomes more complicated by pulp necrosis and development of a combined endodontic-periodontal lesion which is a diagnostic and treatment challenge for the clinician. this report presents the succes...

WOPR-domain proteins are found throughout the fungal kingdom where they function as master regulators of cell morphology and pathogenesis. Genetic and biochemical experiments previously demonstrated that these proteins bind to specific DNA sequences and thereby regulate transcription. However, their primary sequence showed no relationship to any known DNA-binding domain, and the basis for their...

We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)(2), which has two potential AATT interacting groups. Interaction with only one of them is found. The structure presents analogies and significant differences with previous NMR studies: the AT...

A Riemannian-geometry approach for modeling and control of dynamics of object manipulation under holonomic or nonholonomic constraints is presented. First, position/force hybrid control of an endeffector of a multijoint redundant (or nonredundant) robot under a holonomic constraint is reinterpreted in terms of “submersion” in Riemannian geometry. A force control signal constructed in the image ...

This paper presents a new self-clinching fastener to connect two sheets (or plates), made from similar or dissimilar materials, placed over one another by means of mechanical form-closed joint that is hidden inside the sheets. The development fastener, definition its main design variables and identification workability limits are carried out combined experimental numerical simulation work based...

Mitochondria are crucial for many cellular functions. In this issue of Cell Reports, studies from Lanning et al. and Wolf and Mootha describe RNAi approaches to screening the mitochondrial proteome. Unexpectedly, they uncover key roles for two poorly characterized mitochondrial proteins: AK4 and FASTKD4. These studies provide examples of the power of forward genetic screens, even when screening...

Constraint satisfaction has become ubiquitous in the modern world, able to model and offer solution techniques for many of the most pressing problems. However, no matter how good the techniques become, some problems just do not have a satisfiable solution, and are referred to as inconsistent. Yet even when such problems are considered, one is still interested in finding the minimal subset of co...