background: prevention of slipping accidents requires provision of adequate friction through the use of suitable combinations of footwear and underfoot surfaces. shoe sole tread groove is one of the important factors on friction coefficient during walking. objective: to measure the effect of different shoe sole tread groove depths and different surfaces on the required quotient of friction (q),...

no tillage systems can reduce operating costs, enhance soil organic matter, ameliorate soil structure and prevent environmental damage caused by stubble burning. however, the lack of an appropriate direct drill for the hardened soil of arid areas reduces adequate soil-seed contact and, thus, the system has shown contradictory results in past tests. developing a direct drill to place the seed an...

BACKGROUND Given the unreliable self-report in patients with dementia, pain assessment should also rely on the observation of pain behaviors, such as facial expressions. Ideal observers should be well trained and should observe the patient continuously in order to pick up any pain-indicative behavior; which are requisitions beyond realistic possibilities of pain care. Therefore, the need for vi...

We explore the automatic recovery of solids from their binary volumetric discretizations. In particular, we propose an approach, called Pressing, for smoothing isosurfaces extracted from binary volumes while recovering their large planar regions (flats). Pressing yields a surface that is guaranteed to contain the samples of the volume classified as interior and exclude those classified as exter...

Integration of the viral cDNA into host chromosomes is required for viral replication. Human immunodeficiency virus integrase catalyzes two sequential reactions, 3'-processing (3'-P) and strand transfer (ST). The first integrase inhibitors are undergoing clinical trial, but interactions of inhibitors with integrase and DNA are not well understood in the absence of a co-crystal structure. To inc...

Deep-sea pressure vessels are specialized designed for automatic deployment from underwater to the surface. These find extensive applications in life-saving and transportation. Their interiors furnished with a pair of sealing rings, one which is lip-shaped, other convex shape, ensure dependable seal. With increasing water depth, rings experience augmented pressure, resulting gradual pressing in...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 the radicular groove is a developmental anomaly that predisposes the tooth to periodontal break-down. sometimes the situation becomes more complicated by pulp necrosis and development of a combined endodontic-periodontal lesion which is a diagnostic and treatment challenge for the clinician. this report presents the succes...

WOPR-domain proteins are found throughout the fungal kingdom where they function as master regulators of cell morphology and pathogenesis. Genetic and biochemical experiments previously demonstrated that these proteins bind to specific DNA sequences and thereby regulate transcription. However, their primary sequence showed no relationship to any known DNA-binding domain, and the basis for their...

We present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)(2), which has two potential AATT interacting groups. Interaction with only one of them is found. The structure presents analogies and significant differences with previous NMR studies: the AT...