Marriage between close biological kin is widely regarded as genetically disadvantageous in contemporary western societies, but consanguineous unions remain preferential in north africa, the Middle east and large parts of asia, with marriage between first cousins particularly popular. Many major populations also are subdivided into endogamous communities that have distinctive breeding pools. it ...

OBJECTIVES The aim of the study was to determine the extent and nature of consanguinity in the Qatari population and its effects on common adult diseases. SUBJECTS AND METHODS The study was conducted in urban and semi-urban areas of Qatar between October 2004 and May 2005. The total sample of 1,050 married Qatari females 15 years of age and over were approached for study. The degree of consan...

Consanguinity is common in many countries and the rates of Consanguineous Unions (CU) and Inbreeding Coefficient F (ICF) have been observed in various isolated as well as metropolitan populations across the globe (1). Studies on the dynamics of consanguinity in transitory and fragmented populations are however, scarce (2). The Pashtun tribal belt living on both sides of the Durand Line at Pakis...

in this study the clinical and epidemiological characteristics of congenital adrenal hyperplasia were evaluated prospectively in 47 patients admitted in imam reza hospital in mashhad during a 4 year period. 21-hydroxylase deficiency was present in 42 patients (89.3%), the simple virilizing form in 6 and the salt-losing form in 36 of them. 11b hydroxylase deficiency was present in 5 patients (10...

we present 2 cases of likely rare event. in case 1, 3rd degree consanguineous marriage revealed inv(6) with same break points in parents who were found to be phenotypically normal. the same inv(6) being inherited in progeny but presented with low amh (anti mullerian hormone) and high level of fsh (follicular stimulating hormone) leading to polycystic ovarian syndrome/premature ovarian failure. ...

background: autism spectrum disorder (asd) is a neurological disorder typically appearing before the age of three . the exact cause of autism remains uncertain, and several factors may be involved in its onset: genetic factors and possible environmental factors. the aim of this study was to assess the correlates of autism in the lebanese population. methods: we investigated the association of a...

Hemoglobinosis C occurs mainly in Africa and America with a high frequency West Africa. In Senegal, homozygous hemoglobinopathy CC constitutes very rare profile of which only 3 cases are followed the clinical hematology department Dakar. The 1st case is 49-year-old female patient, notion degree consanguinity, long history abdominal pain who presented poorly tolerated anemic syndrome splenomegal...

Introduction: To assess the relationship between parental consanguinity and permanent congenital hypothyroidism (PCH). Materials And Methods: From February 1998 to August 2002, cord dried blood spot samples, viz. only live births, in eight hospitals and a rural birth center in Tehran and Damavand were collected on Whatman BFC 180 filter papers. Samples with cord TSH  20 mU/L (two-site IRMA) ...

A South Wales gypsy kindred of Romany origin had a high incidence of phenylketonuria along with other recessively inherited disorders. There was a high degree of consanguinity (F = 0-017) with an excess of non-specific mental subnormality among known consanguineous matings. Phenylketonuria and a number of other recessively inherited disorders have been recorded from other Romany gypsy populatio...