in this paper, the conjugate gradient method coupled with adjoint problem is used in order to solve the inverse heat conduction problem and estimation of the time- dependent heat flux using the temperature distribution at a point in a three layer system with none homogeneous boundary conditions. also, the effect of noisy data on final solution is studied. for solving this problem the general co...

miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisted of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two...

background and objectives: treatment of pseudomonas aeruginosa infections is greatly hampered by innate and acquired antibiotic resistance. the goal of this study was to compure the immunogenicity of conjugates of p. aeruginosa depolymerized alginate-diphtheria toxoid (d-algdt) and p. aeruginosa detoxified lipopolysaccharidediphtheria toxoid (d-lpsdt) in mouse model. materials and methods: algi...

The primary antibody response elicited from mouse spleen explants by conjugates of the 3-nitro-5-iodo-4-hydroxyphenylacetic acid (NIP) hapten consisted mostly of the IgA class. Poly-L-lysine, pneumococcal polysaccharide Type SIII, keyhole limpet hemocyanin, and sheep erythrocytes were effective carriers in this system, whereas chicken globulin was not. The anti-NIP response against all of the i...

Using a method of H. Davenport and W. M. Schmidt, we show that, for each positive integer n, the ratio 2/n is the optimal exponent of simultaneous approximation to real irrational numbers 1) by all conjugates of algebraic numbers of degree n, and 2) by all but one conjugates of algebraic integers of degree n + 1.

Monoclonal antibodies (mAbs) and their derivatives are currently the fastest growing class of therapeutics. Even if naked antibodies have proven their value as successful biopharmaceuticals, they suffer from some limitations. To overcome suboptimal therapeutic efficacy, immunoglobulins are conjugated with toxic payloads to form antibody drug conjugates (ADCs) and with chelating systems bearing ...

An UPLC-MS/MS method was developed for the determination of serotonin (5-HT), dopamine (DA), their phase I metabolites 5-HIAA, DOPAC and HVA, and their sulfate and glucuronide conjugates in human brain microdialysis samples obtained from two patients with acute brain injuries, ventricular cerebrospinal fluid (CSF) samples obtained from four patients with obstructive hydrocephalus, and a lumbar ...

The use of antibodies in immunodiagnostic kits generally implies the conjugation of these proteins with other molecules such as chromophores or fluorochromes. The development of more sensitive quality control procedures than spectrophotometry is essential to assure the use of better fluorescent conjugates since the fluorescent conjugates are critical reagents for a variety of immunodiagnostic k...

Decision Neural Network is a new approach for solving multi-objective decision-making problems based on artificial neural networks. Using inaccurate evaluation data, network training has improved and the number of educational data sets has decreased. The available training method is based on the gradient decent method (BP). One of its limitations is related to its convergence speed. Therefore,...