Neonatal diagnosis of congenital toxoplasmosis is based on a combination serological and molecular tests. Maternal screening treatment differ according to national policies may impact the sensitivity diagnostic methods in infants at birth.

Untreated acute toxoplasmosis among pregnant women can lead to serious sequelae among newborns, including neurological impairment and blindness. In Brazil, the risk of congenital toxoplasmosis (CTox) has not been fully evaluated. Our aim was to evaluate trends in acute toxoplasmosis prevalence from 1998-2005, the incidence of CTox and the rate of mother-to-child transmission (MTCT). A cross-sec...

A large amount of research has been done on toxoplasmosis in the last 30 years, and the world-wide incidence of the infection, and its clinical manifestations, are recognized and documented in an extensive literature. New discoveries concerning the life-cycle of the organism (Frenkel, I970; Hutchison, Dunachie, Siim, and Work, I970) promise to solve many of the problems of the transmission of i...

BACKGROUND: Toxoplasmosis is a protozoan parasitic infection. The cerebrospinal, ocular and congenital forms of the disease are complicated and life threatening. Diagnosis of toxoplasmosis is difficult due to invasive sample requirement, complications in pathogenesis, immunology, and interpretation of test results. Using urine as a non invasive sample source for molecular diagnosis of toxoplasm...

A large amount of research has been done on toxoplasmosis in the last 30 years, and the world-wide incidence of the infection, and its clinical manifestations, are recognized and documented in an extensive literature. New discoveries concerning the life-cycle of the organism (Frenkel, I970; Hutchison, Dunachie, Siim, and Work, I970) promise to solve many of the problems of the transmission of i...

A study was carried out to evaluate the presence of serological markers for the immunodiagnosis of the vertical transmission of toxoplasmosis. We tested the sensitivity, specificity and predictive values (positive and negative) of different serological methods for the early diagnosis of congenital toxoplasmosis. In a prospective longitudinal study, 50 infants with suspected congenital toxoplasm...

A large amount of research has been done on toxoplasmosis in the last 30 years, and the world-wide incidence of the infection, and its clinical manifestations, are recognized and documented in an extensive literature. New discoveries concerning the life-cycle of the organism (Frenkel, I970; Hutchison, Dunachie, Siim, and Work, I970) promise to solve many of the problems of the transmission of i...

When immunocompetent people become infected with the parasite Toxoplasma gondii, the disease is generally asymptomatic. However, transplacental transmission of T. gondii may lead to severe congenital infection including in utero abortion, foetal death, or neurological or ocular damage of the foetus. France has had a national programme to prevent congenital toxoplasmosis since 1978. However, alt...

Toxoplasmosis when occurring during pregnancy can be transmitted to the fetus and lead to congenital toxoplasmosis (CT). Therefore, pregnant women are a risk group, for which it is necessary to determine the serologic profile. The objective of this study is to determine the serologic profile of toxoplasmosis in pregnant women followed at the Parasitology Laboratory of the Pasteur Institute in T...

The incidence of congenital toxoplasmosis in Fischer rats infected between the 8th and 12th days of pregnancy with three different strains of Toxoplasma gondii (RH, 76K, and Prugniaud) were 58.2, 35.2, and 62.8%, respectively. No infected fetuses were collected from rats previously infected with RH or Prugniaud strain parasites, even if the rats were reinfected during pregnancy. Since pups from...