The pH-regulated M2 proton channel from the influenza A virus has a His-tetrad in its transmembrane (TM) domain that is essential for proton conduction. At neutral pH, the tetrad has been observed in two distinct configurations, the "His-box" and "dimer-of-dimers", with similar backbone structures suggesting competing models for proton conduction. Here, we propose that both conformations can pl...

Determination of the maximum temperature and its location is the matter of the greatest importance in many technological and scientific engineering applications. In terms of numerical calculations of the heat conduction equation by using uniform mesh increments in space, large computational cost is sometimes countered. However, adaptive grid refinement method could be computationally efficient ...

The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulomb blockade, a phenomenon based on charge discreteness and an electrostatic model of an ion channel. This novel approach provides a unified explanation of numerous observed and modelled conductance and selectivity phenomena, including the anomalous mole fraction effect and discrete conduction band...

transcatheteraortic valve implantation, first introduced in 2002, has been established as an alternative modality for patients deemed not suitable for open-heart surgery. the anatomical vicinity of the atrioventricular node and the his bundle to the non-coronary and rightcoronary aortic cusps predisposes patients to conduction abnormalities in case of severe calcification or mechanical trauma d...

Citation: Greiner J, Sankarankutty AC, Seemann G, Seidel T and Sachse FB (2018) Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart. Front. Physiol. 9:239. doi: 10.3389/fphys.2018.00239 Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infar...

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In this paper, a numerical solution of an inverse non-dimensional heat conduction problem by spline method will be considered. The given heat conduction equation, the boundary condition, and the initial condition are presented in a dimensionless form. A set of temperature measurements at a single sensor location inside the heat conduction body is required. The result show that the proposed meth...

numerical solutions obtained by the meshless local petrov–galerkin (mlpg) method are presented for two-dimensional steady-state heat conduction problems. the mlpg method is a truly meshless approach, and neither the nodal connectivity nor the background mesh is required for solving the initial-boundary-value problem. the penalty method is adopted to efficiently enforce the essential boundary co...

BACKGROUND Numerous nerve conduction tests are used for the electrodiagnosis of carpal tunnel syndrome (CTS), with a wide range of sensitivity and specificity reported for each test in clinical studies. The tests have not been assessed in population-based studies. Such information would be important when using electrodiagnosis in epidemiologic research. The purpose of this study was to compare ...