This article develops a method to estimate the impact of change in a particular social setting, the residential neighborhood, that is designed to address nonrandom selection into a neighborhood and nonrandom selection out of a neighborhood. Utilizing matching to confront selection into neighborhood environments and instrumental variables to confront selection out of changing neighborhoods, the ...

Due to high prevalence rates and deleterious effects on individuals, families, and communities, intimate partner violence (IPV) is a significant public health problem. Because IPV occurs in the context of communities and neighborhoods, research must examine the broader environment in addition to individual-level factors to successfully facilitate behavior change. Drawing from the Social Determi...

BACKGROUND Pneumonia and pneumococcal disease cause a large disease burden in resource-constrained settings. We pursue an extended cost-effectiveness analysis (ECEA) of two fully publicly financed interventions in Ethiopia: pneumococcal vaccination for newborns and pneumonia treatment for under-five children in Ethiopia. METHODS We apply ECEA methods and estimate the program impact on: (1) go...

The efficacy and the optimum dose of Fusobacterium necrophorum crude leukotoxoid vaccine required to immunize and protect steers against experimentally induced liver abscesses were evaluated. The vaccine consisted of cell-free culture supernatant of a high leukotoxin-producing strain of F. necrophorum, inactivated with formalin and homogenized with an adjuvant. Twenty-five steers were assigned ...

Rotaviruses are a major cause of acute gastroenteritis in infants and young children worldwide and in many other mammalian and avian host species. Since 2006, two live-attenuated rotavirus vaccines, Rotarix® and RotaTeq®, have been licensed in >100 countries and are applied as part of extended program of vaccination (EPI) schemes of childhood vaccinations. Whereas the vaccines have been highly ...

were concentrated in Fortaleza and the northwest region of the state. Patient age distribution was significantly different between the capital, where the infection most affected children <12 months of age, and the inner cities, where it most affected persons 15–29 years of age. Current heterogeneous measles vaccine coverage (4,5); a delayed response and insufficient vaccination coverage in the ...

The feasibility of a purified, inactivated dengue (DEN) vaccine made in Vero cells was explored. A DEN-2 virus candidate was chosen for production of a monotypic, purified, inactivated vaccine (PIV). Virus was harvested from roller bottle culture supernatants, concentrated, and purified on sucrose gradients. The purified virus was inactivated with 0.05% formalin at 22 degrees C. After inactivat...

has concentrated heavily on virology, while immunology and vaccines commanded the attention that you might expect for, say, the Oscar for best animated short film. But the first day of this year’s CROI offered two parallel morning sessions on virology and immunology and, surprisingly, it was the latter session that was standing room only. In a similar shift, vaccines commanded a special symposi...

Genotyping circulating rotaviruses before and after introduction of rotavirus vaccine is useful for evaluating vaccine-associated changes in genotype distribution. We determined frequency of rotavirus genotypes among 61 rotavirus-positive children hospitalized in Israel during the 2005-06 rotavirus season. Accurate molecular epidemiologic data were recovered from affinity-concentrated rotavirus...