In a preliminary study we observed that piglets suffering from chronic lung inflammation induced by an intravenous injection of complete Freund adjuvant showed a marked decrease in plasma tryptophan (Trp) concentration suggesting increased Trp utilisation. During the inflammatory process, a cytokine-induced enzyme called indoleamine 2,3-dioxygenase (IDO) has been shown to catabolise Trp into ky...

Atherosclerosis is a complex disease, bearing many of the characteristics of a chronic inflammatory process. Both cellular and humoral immune responses may be involved in the disease development. Oxidized low-density lipoprotein (oxLDL) is suggested to be an autoantigen in atherosclerosis. A protective effect against atherosclerosis has been demonstrated in animals immunized with oxLDL. Such a ...

Previous passive antibody transfer experiments have indicated that immunity to a 46-kilodalton membrane glycoprotein (M-2) of Leishmania amazonensis may protect against infection with this parasite. In the studies described in this paper, we investigated the ability of the purified M-2 molecule to elicit a protective immune response in conjunction with Freund incomplete and complete adjuvants, ...

Attempts were made to prevent methylcholanthrene tumorigenesis in mice by immunization with the insoluble lipoprotein of methylcholanthrene-induced sarcomas of the same strain of mice. Swiss/Mk mice were intensively immunized with the insoluble lipoprotein fraction extracted by the Thomas method or with the supernatant fraction of isogenic methylcholanthrene-induced tumor cells, or normal cells...

introduction: the activity of hypothalamus-pituitary-adrenal (hpa) axis is increased following inflammation due to its closed relation with immune system. this axis indicates an increased secretion of acth, and corticosterone during acute inflammation while little is known about its activity during chronic inflammation such as rheumatoid arthritis (ra). in this study we measured the products of...