نتایج جستجو برای: complementing group 1 xrcc1 gene

تعداد نتایج: 4202903  

2013
Xin Deng Jian Liang Majun Jiang Xiaoxiao Zhou Hongdan Liu

The human X-ray repair complementing group 1 gene (XRCC1) is an important candidate gene influencing hepatocellular carcinoma (HCC) susceptibility. The objective of this study was to detect the association between c.1161G>A and c.1779C>G variants of XRCC1 gene and HCC risk. This study was conducted in Chinese population consisting of 623 HCC cases and 639 controls. These two genetic variants co...

2017
Ying-Nan Wang De-Wei Wang Lei Gao Shi-Yong Wu Dong-Yin Zhang Shu Qin

Background: Two meta-analyses assessed the association between X-Ray Repair Cross Complementing 1 (XRCC1) gene polymorphisms and Coronary Artery Disease (CAD) risk. However, these two metaanalyses all included the studies without Hardy-Weinberg equilibrium (HWE). Therefore, their results were not reliable. Methods: PubMed, EMBASE, MEDLINE, and the Cochrane Library were searched up to May 2017. ...

Journal: :Genetics and molecular research : GMR 2016
J Z Zhao X R Tan M Zhao X C Mao L Jiang

Previous case-control studies having investigated the relationship between the X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and thyroid cancer (TC) have drawn inconsistent conclusions. The current study aimed to clarify the role of this polymorphism in susceptibility to TC. An up-to-date search of PubMed and Web of Science databases was conducted, including articles p...

2015
Menglong Xiang Lei Sun Xiaomei Dong Huan Yang Wen-bin Liu Niya Zhou Xue Han Ziyuan Zhou Zhihong Cui Jing-yi Liu Jia Cao Lin Ao

The aim of the study was to examine the association between polymorphisms of DNA repair genes and chromosomal damage of 1,3-butadiene- (BD-) exposed workers. The study was conducted in 45 pairs of occupationally exposed workers in a BD product workshop and matched control workers in an administrative office and a circulatory water workshop in China. Newly developed biomarkers (micronuclei, MNi;...

Journal: :Antioxidants & redox signaling 2013
Tarek Abdel-Fatah Arvind Arora Ipek Gorguc Rachel Abbotts Sarah Beebeejaun Sarah Storr Vivek Mohan Claire Hawkes Irshad Soomro Dileep N Lobo Simon L Parsons Srinivasan Madhusudan

Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glycosylase 1 [SMUG1], Flap endonuclease 1 [FEN1], X-ray repair cross-complementing...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Hao Luo Zheng Li Yi Qing Shi-Heng Zhang Yu Peng Qing Li Dong Wang

Altered DNA repair capacity can result in increased susceptibility to cancer. The base excision repair (BER) pathway effectively removes DNA damage caused by ionizing radiation and reactive oxidative species (ROS). In the current study, we analyzed the possible relation of polymorphisms in BER genes, including 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), and...

2012
Guang Yin Makiko Morita Keizo Ohnaka Kengo Toyomura Nobuyuki Hamajima Tetsuya Mizoue Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Yohichi Yasunami Takefumi Maekawa Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka

BACKGROUND X-ray cross-complementing group 1 (XRCC1) polymorphisms affect DNA repair capacity and may therefore be of importance in colorectal carcinogenesis. Alcohol consumption, an important risk factor for colorectal cancer, may induce carcinogenesis through DNA damage caused by the toxic effects of alcohol or its metabolites. Therefore, we examined the associations of XRCC1 Arg399Gln, Arg28...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002
Jae Yong Park Su Yeon Lee Hyo-Sung Jeon Nack Chun Bae Sang Chul Chae Soyoung Joo Chang Ho Kim Jae-Ho Park Sin Kam In San Kim Tae Hoon Jung

DNA repair plays a critical role in protecting the genome of the cell from insults of cancer-causing agents, such as those found in tobacco smoke. Reduced DNA repair capacity, therefore, can increase the susceptibility to smoking-related cancers. Recently, three coding polymorphisms in X-ray cross-complementing group 1 (XRCC1) DNA repair gene have been identified, and it is possible that these ...

2004
Wei-Min Gao Marjorie Romkes Jill M. Siegfried James D. Luketich Phouthone Keohavong

Lung cancer is strongly associated with exposure to tobacco smoke (1–3). Mutations in the K-ras gene have been found in 20–35% of lung adenocarcinomas of smokers (4–8), compared with about 5–7% in those of nonsmokers (7, 8), suggesting that their formation may be associated with exposure to tobacco smoke carcinogens. DNA repair helps preserve the integrity of the cellular genome by repairing DN...

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