نتایج جستجو برای: compensatory amounts
تعداد نتایج: 121981 فیلتر نتایج به سال:
Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse line...
Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse line...
Leber’s hereditary optic neuropathy (LHON) is a disease that affects the optical nerve, causing visual loss. The diagnosis of LHON mostly defined by identification three pathogenic variants in mitochondrial DNA. Idebenone widely used to treat patients, but only some them are responders treatment. In our study, we assessed maximal respiration rate (MRR) and other respiratory parameters eight fib...
Background: Primary hyperhidrosis (PH) refers to excessive sweating, beyond normal physiological levels, in specific sites of the body for unknown reasons. It is usually bilateral and is most prominent in the palms, axillae, feet, and face. PH prevalence is estimated to be 0%-6.1% in different populations. It usually begins in childhood and is more frequent in women. In 57% of ...
The compensatory growth, proximate composition and amino acid contents changes of young yellow catfish (Pelteobagrus fulvidraco R.) (1.63-1.69 g) had been investigated using a 45-day cyclic feed deprivation and re-feeding experiment. The control group (S0) was fed daily with live tubificid worms (Limnodrilus hoffmeisteri), while the S1/4, S1/2, and S1/1 groups cyclically experienced one-day of ...
Adult bone marrow is a major site for hematopoiesis, and reduction of the bone marrow cavity induces hematopoiesis in extramarrow tissues. To investigate the rudimentary intramarrow and the compensatory extramarrow hematopoiesis, particularly B lymphopoiesis, we used 3 osteopetrotic mouse strains [op/op, mi/mi, and Fos (-/-)], which are severely deficient in functional osteoclasts and therefore...
The majority of cellular energy is produced by the mitochondrial oxidative phosphorylation (OXPHOS) system. Failure first OXPHOS enzyme complex, NADH:ubiquinone oxidoreductase or complex I (CI), associated with multiple signs and symptoms presenting at variable ages onset. There no approved drug treatment yet to slow reverse progression CI-deficient disorders. Here, we present a comprehensive h...
Compensatory mutations improve fitness in genotypes that contain deleterious mutations but have no beneficial effects otherwise. As such, compensatory mutations represent a very specific form of epistasis. We show that intragenic compensatory mutations occur non-randomly over gene sequence. Compensatory mutations are more likely to appear at some sites than others. Moreover, the sites of compen...
Ehsan Rule and the effects on it in terms of compensatory and non-compensatory liabilities are of great importance; to the extent that it independently and initially revokes the liability based on a famous view among jurists and Jurisprudents. Based on the mentioned-view, in order to trigger Ehsan Rule and termination of liability, intentional and actual benefaction should necessarily exist. De...
Introduction: Decision making about surgery in patients with submucous cleft palate (SMCP) is usually postponed until speech assessment is applicable. Therefore, these patients spend more years with disorders associated with cleft. This study was aimed to investigate and compare the prevalence of different communication disorders in patients with unrepaired SMCP at different ages, since this in...
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