نتایج جستجو برای: compelement c3
تعداد نتایج: 16430 فیلتر نتایج به سال:
BACKGROUND Recent studies have demonstrated the key role of the complement alternative pathway (cAP) in the pathophysiology of experimental ANCA-associated vasculitis (AAV). However, in human AAV the role of cAP has not been extensively explored. In the present work, we analysed circulating serum C3 levels measured at AAV onset and their relation to outcomes. METHODS We conducted a retrospect...
In experiments to ascertain the biochemical basis of a genetically determined deficiency of the third component of complement (C3) in guinea pigs, we found that C3-deficient liver and peritoneal macrophages contain C3 messenger RNA of normal size (approximately 5 kb) and amounts, that this mRNA programs synthesis of pro-C3 in oocytes primed with liver RNA and in primary macrophage cultures. In ...
The slow but spontaneous and ubiquitous formation of C3(H2O), the hydrolytic and conformationally rearranged product of C3, initiates antibody-independent activation of the complement system that is a key first line of antimicrobial defense. The structure of C3(H2O) has not been determined. Here we subjected C3(H2O) to quantitative cross-linking/mass spectrometry (QCLMS). This revealed details ...
A hypomorphic electrophoretic variant of C3 with the mobility of C3 F was found in the serum of a healthy man, his mother, and one of his two sons. Serum C3 concentrations were normal in these subjects as were hemolytic complement levels. Metabolic studies with radiolabeled purified C3 FF and C3 SS in the propositus suggested, but did not prove, that the variant C3 F gene was hyposynthetic. The...
A ghost in the stable module category of a group G is a map between representations of G that is invisible to Tate cohomology. We show that the only non-trivial finite p-groups whose stable module categories have no non-trivial ghosts are the cyclic groups C2 and C3. We compare this to the situation in the derived category of a commutative ring. We also determine for which groups G the second p...
مقدمه: بیماری عروق کرونر از شایع ترین و مهم ترین علل مرگ در جهان است. زمینه ساز اصلی بیماری، آترواسکلروز عروق کرونراست. این بیماریهای عروق کرونردارای طیف وسیعی است که در یک سر طیف ایسکمی بدون علامت و در سر دیگر طیف، مرگ ناگهانی است. هدف این مطالعه بررسی تفاوت ها و مقایسه تغییرات اجزای c3 و c4 کمپلمان در این دو بیماری است. تا شاید بتوان از این اجزا به عنوان شاخص هایی برای تعیین پیش آگهی و عوارض ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید