Antimicrobial synergy resulting from antibiotic combination therapy is often important in the treatment of serious bacterial infections. Previous studies have demonstrated synergy between an aminoglycoside and beta-lactam antibiotics in the treatment of Pseudomonas aeruginosa infections. The present paper investigates the synergic effects of aminoglycosides (amikacin and netilmicin) and fluoroq...

This paper offers a mechanistic account of back pain which attempts to incorporate all of the most important recent advances in spinal research. Anatomical and pain-provocation studies show that severe and chronic back pain most often originates in the lumbar intervertebral discs, the apophyseal joints, and the sacroiliac joints. Psychosocial factors influence many aspects of back pain behaviou...

in view of potential biological activities of small molecule polyamides, we synthesized some novel n-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamide (7a,b), and n-(2-(1-benzyl-2-(alkylthio) -1h-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1h-imidazole-5-carboxamides (8a,b) as antitumor agents. the antitumor activity of compounds 7a,b and 8a,b was studied at concent...

G laucoma is a disease characterised by apoptotic ganglion cell death related, at least in part, to intraocular pressure. Any examination for glaucoma must therefore include some comment upon the health of these cells. Unfortunately, it is difficult to examine the ganglion cell layer ophthalmoscopically and so ophthalmologists typically rely on an analysis of a more visible ocular structure—the...

Artificial Intelligence (AI), robotics, co-robotics (cobots), quantum computers (QC), include surges of scientific endeavor to produce machines (mechanical and software) among numerous types and constructions that are accelerating progress to defeat infectious diseases. There is a plethora of additional applications and uses of these methodologies and technologies for the understanding of biome...

One-third of the people with an age over twenty have some signs of degenerated discs. However, in most of the patients the mere presence of degenerative discs is not a problem leading to pain, neurological compression, or other symptoms. This paper presents an interval type-2 fuzzy hybrid rule-based system to diagnose the abnormal degenerated discs where pain variables are represented by interv...

The function of the automotive braking system is to reduce vehicle’s speed or stop within a stipulated time. An efficient dissipates all heat generated during into environment before subsequent applied. heating and cooling cycles, in combination with mechanical loads operation, cause thermal stresses on surface brake disc. resulting thermomechanical fatigue (TMF) disc life-limiting factor cause...

one-third of the people with an age over twenty have some signs of degenerated discs. however, in most of the patients the mere presence of degenerative discs is not a problem leading to pain, neurological compression, or other symptoms. this paper presents an interval type-2 fuzzy hybrid rule-based system to diagnose the abnormal degenerated discs where pain variables are represented by interv...

This paper describes a new methodology for automatic location of the optic disc in retinal images, based on the combination of information taken from the blood vessel network with intensity data. The distribution of vessel orientations around an image point is quantified using the new concept of entropy of vascular directions. The robustness of the method for OD localization is improved by cons...